Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 2256834..2257573 | Replicon | chromosome |
| Accession | NZ_CP045485 | ||
| Organism | Enterobacter cloacae strain 88701 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | GEA56_RS10770 | Protein ID | WP_063451300.1 |
| Coordinates | 2256834..2257319 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A4R0FU91 |
| Locus tag | GEA56_RS10775 | Protein ID | WP_063451299.1 |
| Coordinates | 2257307..2257573 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GEA56_RS10740 | 2252324..2252896 | + | 573 | WP_203463306.1 | NAD(P)H-dependent oxidoreductase | - |
| GEA56_RS10745 | 2252899..2253918 | + | 1020 | WP_203463307.1 | aldo/keto reductase | - |
| GEA56_RS10750 | 2253957..2254334 | + | 378 | WP_063451302.1 | DUF1330 domain-containing protein | - |
| GEA56_RS10755 | 2254371..2254976 | + | 606 | WP_120286599.1 | NAD(P)H-dependent oxidoreductase | - |
| GEA56_RS10760 | 2255017..2255712 | + | 696 | WP_203464647.1 | antibiotic biosynthesis monooxygenase | - |
| GEA56_RS10765 | 2255728..2256531 | + | 804 | WP_203463308.1 | carboxymuconolactone decarboxylase family protein | - |
| GEA56_RS10770 | 2256834..2257319 | - | 486 | WP_063451300.1 | GNAT family N-acetyltransferase | Toxin |
| GEA56_RS10775 | 2257307..2257573 | - | 267 | WP_063451299.1 | DUF1778 domain-containing protein | Antitoxin |
| GEA56_RS10780 | 2257661..2258575 | - | 915 | WP_063451298.1 | LysR family transcriptional regulator | - |
| GEA56_RS10785 | 2258702..2260084 | + | 1383 | WP_102751173.1 | DHA2 family efflux MFS transporter permease subunit | - |
| GEA56_RS10790 | 2260097..2261092 | - | 996 | WP_102751172.1 | DUF2891 domain-containing protein | - |
| GEA56_RS10795 | 2261102..2262088 | - | 987 | WP_063866697.1 | DUF979 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2243246..2257573 | 14327 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17659.40 Da Isoelectric Point: 9.8551
>T141934 WP_063451300.1 NZ_CP045485:c2257319-2256834 [Enterobacter cloacae]
VGRVTAPEPLTSVHQLAEFFSGEAVLDEWIKQRGLKNQALGAARTFVVCKTGTKQVAGYYSLATGSVNHTEATGNLRRNM
PDPIPVIVLARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFRASQIQERTLFLRLP
Q
VGRVTAPEPLTSVHQLAEFFSGEAVLDEWIKQRGLKNQALGAARTFVVCKTGTKQVAGYYSLATGSVNHTEATGNLRRNM
PDPIPVIVLARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFRASQIQERTLFLRLP
Q
Download Length: 486 bp
>T141934 NZ_CP060242:c218861-218283 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAAGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAAGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10090.50 Da Isoelectric Point: 4.3837
>AT141934 WP_063451299.1 NZ_CP045485:c2257573-2257307 [Enterobacter cloacae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPALEKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPALEKLL
ARKPQWDV
Download Length: 267 bp
>AT141934 NZ_CP060242:c219504-218950 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCATCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGACGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGATGGACGCGCGGTACGCCTGGTGGAAACCCTCTGA
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCATCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGACGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGATGGACGCGCGGTACGCCTGGTGGAAACCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|