Detailed information of TA system TA141930

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 56023..56516
• Replicon: chromosome
• Accession: NZ_CP045485
• Organism: Enterobacter cloacae strain 88701

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GEA56_RS00290
• Protein ID: WP_203463947.1
• Coordinates: 56286..56516 (+)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GEA56_RS00285
• Protein ID: WP_203463946.1
• Coordinates: 56023..56286 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEA56_RS00260	51238..52359	-	1122	WP_203463944.1	efflux RND transporter periplasmic adaptor subunit	-
GEA56_RS00265	52507..53076	-	570	WP_203463945.1	TetR/AcrR family transcriptional regulator	-
GEA56_RS00270	53263..53682	+	420	WP_063452086.1	GNAT family N-acetyltransferase	-
GEA56_RS00275	53679..54326	-	648	WP_063452215.1	TetR/AcrR family transcriptional regulator	-
GEA56_RS00280	54406..55905	+	1500	WP_102749930.1	MFS transporter	-
GEA56_RS00285	56023..56286	+	264	WP_203463946.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GEA56_RS00290	56286..56516	+	231	WP_203463947.1	PIN domain-containing protein	Toxin
GEA56_RS00295	56706..57506	+	801	WP_203463948.1	lipoprotein NlpA	-
GEA56_RS00300	57525..58205	-	681	WP_203463949.1	EAL domain-containing protein	-
GEA56_RS00305	58281..58901	-	621	WP_063868682.1	response regulator transcription factor	-
GEA56_RS00310	59477..60112	+	636	WP_063452216.1	LuxR family transcriptional regulator	-
GEA56_RS00315	60119..61183	-	1065	WP_102749927.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-57)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 8574.91 Da
• Isoelectric Point: 6.2097

>T141930 WP_203463947.1 NZ_CP045485:56286-56516 [Enterobacter cloacae]
MRHMLDTNIVSHLFKKHPEVVTRMAGLRPREVCISSITEAELLYGADKKQNSELKETILSFLDTITICAWDSEAAA

Nucleotide

• Length: 231 bp

>T141930 NZ_CP060241:1867952-1868707 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGACGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGCGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGGCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10115.48 Da
• Isoelectric Point: 6.9834

>AT141930 WP_203463946.1 NZ_CP045485:56023-56286 [Enterobacter cloacae]
MERTAKLFKKGRHQAVVLPEEFAFETESVYIRRDEEGKVVLTPKAEQLKTWDNFFRLLGNTNVPDSFLSKEERNQSVTKR
DPLDGVC

Nucleotide

• Length: 264 bp

>AT141930 NZ_CP060241:1867449-1867817 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA