Detailed information of TA system TA141928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2658877..2659483
• Replicon: chromosome
• Accession: NZ_CP045484
• Organism: Sulfurisphaera ohwakuensis strain TA-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1869_RS14415
• Protein ID: WP_221267135.1
• Coordinates: 2658877..2659251 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D1869_RS14420
• Protein ID: WP_156015745.1
• Coordinates: 2659262..2659483 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1869_RS14395 (D1869_14430)	2654874..2655119	-	246	WP_156015741.1	VapB-type antitoxin	-
D1869_RS14400 (D1869_14435)	2655769..2656121	+	353	Protein_2895	ISNCY family transposase	-
D1869_RS14405 (D1869_14440)	2656341..2656982	+	642	WP_156015742.1	metallophosphoesterase	-
D1869_RS14410 (D1869_14445)	2657851..2658297	-	447	WP_156015743.1	alanyl-tRNA editing protein	-
D1869_RS14415 (D1869_14450)	2658877..2659251	-	375	WP_221267135.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1869_RS14420 (D1869_14455)	2659262..2659483	-	222	WP_156015745.1	hypothetical protein	Antitoxin
D1869_RS14425 (D1869_14460)	2659838..2660077	-	240	WP_231113650.1	nucleotidyltransferase domain-containing protein	-
D1869_RS15745	2660131..2660271	-	141	WP_269203976.1	hypothetical protein	-
D1869_RS14435 (D1869_14470)	2660779..2662518	+	1740	WP_156015746.1	prolyl oligopeptidase family serine peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-116)

Antitoxin

• Putative antitoxin VapB3-like (1-73)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14178.74 Da
• Isoelectric Point: 9.2761

>T141928 WP_221267135.1 NZ_CP045484:c2659251-2658877 [Sulfurisphaera ohwakuensis]
MAKFITKEKGWEKITEILKDAETLDFALVEVSNVVWKKVVLTRELTEQDAVKAVTIIRDYLPQLLTLNKSVDLIERAIEI
SMKEKITIYDSLYIALAERKGSKLVTGDKKQHGIAKKYIISELI

Nucleotide

• Length: 375 bp

>T141928 NZ_CP060240:c5567665-5567387 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 9029.27 Da
• Isoelectric Point: 4.7999

>AT141928 WP_156015745.1 NZ_CP045484:c2659483-2659262 [Sulfurisphaera ohwakuensis]
MKTVYSLRIDKELREEMEKYDVKWNEEIENFIRRRIEELKKEEILKKINEILQTMPETKSNSAELVREDRDNN

Nucleotide

• Length: 222 bp

>AT141928 NZ_CP060240:c5567375-5567070 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG