Detailed information of TA system TA141927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/NGN_SP(toxin)
• Location: 2155813..2156366
• Replicon: chromosome
• Accession: NZ_CP045484
• Organism: Sulfurisphaera ohwakuensis strain TA-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1869_RS11990
• Protein ID: WP_231113623.1
• Coordinates: 2156073..2156366 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D1869_RS11985
• Protein ID: WP_231113815.1
• Coordinates: 2155813..2155956 (+)
• Length: 48 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1869_RS11945 (D1869_11985)	2151813..2152022	-	210	WP_156015279.1	hypothetical protein	-
D1869_RS11950 (D1869_11990)	2152247..2152564	-	318	WP_156015281.1	hypothetical protein	-
D1869_RS11955 (D1869_11995)	2152655..2152831	+	177	WP_156015283.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
D1869_RS11960 (D1869_12000)	2152882..2153097	+	216	WP_156015285.1	hypothetical protein	-
D1869_RS11965 (D1869_12005)	2153321..2153938	+	618	WP_156015287.1	hypothetical protein	-
D1869_RS11970 (D1869_12010)	2153948..2154223	-	276	WP_156015288.1	hypothetical protein	-
D1869_RS11975 (D1869_12015)	2154216..2154473	-	258	WP_156015290.1	hypothetical protein	-
D1869_RS11980 (D1869_12020)	2154571..2155446	-	876	WP_231113622.1	integrase	-
D1869_RS11985 (D1869_12025)	2155813..2155956	+	144	WP_231113815.1	hypothetical protein	Antitoxin
D1869_RS15720	2155925..2156053	+	129	WP_260311110.1	hypothetical protein	-
D1869_RS11990 (D1869_12030)	2156073..2156366	+	294	WP_231113623.1	PIN domain-containing protein	Toxin
D1869_RS11995 (D1869_12035)	2156481..2157677	-	1197	WP_156015292.1	glycosyltransferase	-
D1869_RS12000 (D1869_12040)	2157903..2159228	+	1326	WP_231113624.1	transposase	-
D1869_RS12005 (D1869_12045)	2160209..2161192	-	984	WP_156015294.1	glycosyltransferase family A protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2157903..2159228	1325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11089.04 Da
• Isoelectric Point: 6.4685

>T141927 WP_231113623.1 NZ_CP045484:2156073-2156366 [Sulfurisphaera ohwakuensis]
MSEVNLAEFLYLYILKMGKEIAIARHRYIFRNSPIKILAPNENITQSTAILKSKYHYLSLADVFLIATVKEIGGKIITTD
EDIEKTKEVEVIMISLD

Nucleotide

• Length: 294 bp

>T141927 NZ_CP060240:c4692472-4692173 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin

Protein

• Length: 48 a.a.
• Molecular weight: 5192.15 Da
• Isoelectric Point: 6.2570

>AT141927 WP_231113815.1 NZ_CP045484:2155813-2155956 [Sulfurisphaera ohwakuensis]
IKEGDILELKVNGNKIDIGKPMTLLDLFGVDGKVAVEVAKEVIKERR

Nucleotide

• Length: 144 bp

>AT141927 NZ_CP060240:c4692176-4691886 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA