Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/NGN_SP(toxin)
Location 2155813..2156366 Replicon chromosome
Accession NZ_CP045484
Organism Sulfurisphaera ohwakuensis strain TA-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1869_RS11990 Protein ID WP_231113623.1
Coordinates 2156073..2156366 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1869_RS11985 Protein ID WP_231113815.1
Coordinates 2155813..2155956 (+) Length 48 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1869_RS11945 (D1869_11985) 2151813..2152022 - 210 WP_156015279.1 hypothetical protein -
D1869_RS11950 (D1869_11990) 2152247..2152564 - 318 WP_156015281.1 hypothetical protein -
D1869_RS11955 (D1869_11995) 2152655..2152831 + 177 WP_156015283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
D1869_RS11960 (D1869_12000) 2152882..2153097 + 216 WP_156015285.1 hypothetical protein -
D1869_RS11965 (D1869_12005) 2153321..2153938 + 618 WP_156015287.1 hypothetical protein -
D1869_RS11970 (D1869_12010) 2153948..2154223 - 276 WP_156015288.1 hypothetical protein -
D1869_RS11975 (D1869_12015) 2154216..2154473 - 258 WP_156015290.1 hypothetical protein -
D1869_RS11980 (D1869_12020) 2154571..2155446 - 876 WP_231113622.1 integrase -
D1869_RS11985 (D1869_12025) 2155813..2155956 + 144 WP_231113815.1 hypothetical protein Antitoxin
D1869_RS15720 2155925..2156053 + 129 WP_260311110.1 hypothetical protein -
D1869_RS11990 (D1869_12030) 2156073..2156366 + 294 WP_231113623.1 PIN domain-containing protein Toxin
D1869_RS11995 (D1869_12035) 2156481..2157677 - 1197 WP_156015292.1 glycosyltransferase -
D1869_RS12000 (D1869_12040) 2157903..2159228 + 1326 WP_231113624.1 transposase -
D1869_RS12005 (D1869_12045) 2160209..2161192 - 984 WP_156015294.1 glycosyltransferase family A protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2157903..2159228 1325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11089.04 Da        Isoelectric Point: 6.4685

>T141927 WP_231113623.1 NZ_CP045484:2156073-2156366 [Sulfurisphaera ohwakuensis]
MSEVNLAEFLYLYILKMGKEIAIARHRYIFRNSPIKILAPNENITQSTAILKSKYHYLSLADVFLIATVKEIGGKIITTD
EDIEKTKEVEVIMISLD

Download         Length: 294 bp

>T141927 NZ_CP060240:c4692472-4692173 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 48 a.a.        Molecular weight: 5192.15 Da        Isoelectric Point: 6.2570

>AT141927 WP_231113815.1 NZ_CP045484:2155813-2155956 [Sulfurisphaera ohwakuensis]
IKEGDILELKVNGNKIDIGKPMTLLDLFGVDGKVAVEVAKEVIKERR

Download         Length: 144 bp

>AT141927 NZ_CP060240:c4692176-4691886 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References