Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1799649..1800240 Replicon chromosome
Accession NZ_CP045484
Organism Sulfurisphaera ohwakuensis strain TA-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1869_RS09965 Protein ID WP_156014969.1
Coordinates 1799649..1800017 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1869_RS09970 Protein ID WP_156014970.1
Coordinates 1799998..1800240 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1869_RS09930 (D1869_09970) 1794652..1795665 - 1014 Protein_1993 transposase -
D1869_RS09935 (D1869_09975) 1795894..1796223 - 330 WP_156014965.1 nucleotidyltransferase domain-containing protein -
D1869_RS09940 (D1869_09980) 1796207..1796623 - 417 WP_156014966.1 HEPN domain-containing protein -
D1869_RS09945 (D1869_09985) 1796814..1797227 + 414 WP_156014967.1 HEPN domain-containing protein -
D1869_RS09950 (D1869_09990) 1797215..1797538 + 324 WP_231113594.1 nucleotidyltransferase domain-containing protein -
D1869_RS09955 (D1869_10000) 1798042..1798263 + 222 WP_231113595.1 DUF4322 domain-containing protein -
D1869_RS09960 (D1869_10005) 1798351..1799424 + 1074 Protein_1999 transposase -
D1869_RS09965 (D1869_10010) 1799649..1800017 - 369 WP_156014969.1 PIN domain-containing protein Toxin
D1869_RS09970 (D1869_10015) 1799998..1800240 - 243 WP_156014970.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D1869_RS09975 (D1869_10020) 1800775..1801127 + 353 Protein_2002 IS1 family transposase -
D1869_RS09980 (D1869_10025) 1801131..1802093 - 963 WP_231113596.1 IS200/IS605 family accessory protein TnpB-related protein -
D1869_RS15530 1802132..1802449 - 318 WP_231113597.1 hypothetical protein -
D1869_RS09985 (D1869_10030) 1802421..1803029 - 609 WP_156014971.1 IS607 family transposase -
D1869_RS09990 (D1869_10035) 1803078..1803221 + 144 Protein_2006 IS1 family transposase -
D1869_RS09995 (D1869_10040) 1803292..1803516 + 225 WP_156014972.1 type II toxin-antitoxin system CcdA family antitoxin -
D1869_RS10000 (D1869_10045) 1803513..1803872 + 360 WP_156014973.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1791064..1803221 12157
- inside IScluster/Tn - - 1798351..1803221 4870


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

SpoVT-AbrB domain

(4-46)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14301.57 Da        Isoelectric Point: 4.9617

>T141926 WP_156014969.1 NZ_CP045484:c1800017-1799649 [Sulfurisphaera ohwakuensis]
MEEVVVDTNFVIAVIFEDHIFHKLAIDDWGKIHKAYLPIIAVSELAYFLIKNRFNLDDVLENVLSDPKIEVVENTLEDVY
FTIKNSPKSYDDFNDYMIISLAKRLGLKILTYDEKMKRKQKS

Download         Length: 369 bp

>T141926 NZ_CP060240:c4692176-4691886 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 9.9635

>AT141926 WP_156014970.1 NZ_CP045484:c1800240-1799998 [Sulfurisphaera ohwakuensis]
MEEVKVTRNYQITIPSTIRAKLNIRVGDKLLVYVENNKIIIEKKSGNITSLNLKLGRKFTDEDINKIIAEAGEEIGRSSS

Download         Length: 243 bp

>AT141926 NZ_CP060240:c4692472-4692173 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References