Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-AbrB |
| Location | 1799649..1800240 | Replicon | chromosome |
| Accession | NZ_CP045484 | ||
| Organism | Sulfurisphaera ohwakuensis strain TA-1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | D1869_RS09965 | Protein ID | WP_156014969.1 |
| Coordinates | 1799649..1800017 (-) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | D1869_RS09970 | Protein ID | WP_156014970.1 |
| Coordinates | 1799998..1800240 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D1869_RS09930 (D1869_09970) | 1794652..1795665 | - | 1014 | Protein_1993 | transposase | - |
| D1869_RS09935 (D1869_09975) | 1795894..1796223 | - | 330 | WP_156014965.1 | nucleotidyltransferase domain-containing protein | - |
| D1869_RS09940 (D1869_09980) | 1796207..1796623 | - | 417 | WP_156014966.1 | HEPN domain-containing protein | - |
| D1869_RS09945 (D1869_09985) | 1796814..1797227 | + | 414 | WP_156014967.1 | HEPN domain-containing protein | - |
| D1869_RS09950 (D1869_09990) | 1797215..1797538 | + | 324 | WP_231113594.1 | nucleotidyltransferase domain-containing protein | - |
| D1869_RS09955 (D1869_10000) | 1798042..1798263 | + | 222 | WP_231113595.1 | DUF4322 domain-containing protein | - |
| D1869_RS09960 (D1869_10005) | 1798351..1799424 | + | 1074 | Protein_1999 | transposase | - |
| D1869_RS09965 (D1869_10010) | 1799649..1800017 | - | 369 | WP_156014969.1 | PIN domain-containing protein | Toxin |
| D1869_RS09970 (D1869_10015) | 1799998..1800240 | - | 243 | WP_156014970.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| D1869_RS09975 (D1869_10020) | 1800775..1801127 | + | 353 | Protein_2002 | IS1 family transposase | - |
| D1869_RS09980 (D1869_10025) | 1801131..1802093 | - | 963 | WP_231113596.1 | IS200/IS605 family accessory protein TnpB-related protein | - |
| D1869_RS15530 | 1802132..1802449 | - | 318 | WP_231113597.1 | hypothetical protein | - |
| D1869_RS09985 (D1869_10030) | 1802421..1803029 | - | 609 | WP_156014971.1 | IS607 family transposase | - |
| D1869_RS09990 (D1869_10035) | 1803078..1803221 | + | 144 | Protein_2006 | IS1 family transposase | - |
| D1869_RS09995 (D1869_10040) | 1803292..1803516 | + | 225 | WP_156014972.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| D1869_RS10000 (D1869_10045) | 1803513..1803872 | + | 360 | WP_156014973.1 | type II toxin-antitoxin system VapC family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1791064..1803221 | 12157 | |
| - | inside | IScluster/Tn | - | - | 1798351..1803221 | 4870 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 14301.57 Da Isoelectric Point: 4.9617
>T141926 WP_156014969.1 NZ_CP045484:c1800017-1799649 [Sulfurisphaera ohwakuensis]
MEEVVVDTNFVIAVIFEDHIFHKLAIDDWGKIHKAYLPIIAVSELAYFLIKNRFNLDDVLENVLSDPKIEVVENTLEDVY
FTIKNSPKSYDDFNDYMIISLAKRLGLKILTYDEKMKRKQKS
MEEVVVDTNFVIAVIFEDHIFHKLAIDDWGKIHKAYLPIIAVSELAYFLIKNRFNLDDVLENVLSDPKIEVVENTLEDVY
FTIKNSPKSYDDFNDYMIISLAKRLGLKILTYDEKMKRKQKS
Download Length: 369 bp
>T141926 NZ_CP060240:c4692176-4691886 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9018.43 Da Isoelectric Point: 9.9635
>AT141926 WP_156014970.1 NZ_CP045484:c1800240-1799998 [Sulfurisphaera ohwakuensis]
MEEVKVTRNYQITIPSTIRAKLNIRVGDKLLVYVENNKIIIEKKSGNITSLNLKLGRKFTDEDINKIIAEAGEEIGRSSS
MEEVKVTRNYQITIPSTIRAKLNIRVGDKLLVYVENNKIIIEKKSGNITSLNLKLGRKFTDEDINKIIAEAGEEIGRSSS
Download Length: 243 bp
>AT141926 NZ_CP060240:c4692472-4692173 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|