Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 825211..825814 Replicon chromosome
Accession NZ_CP045484
Organism Sulfurisphaera ohwakuensis strain TA-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1869_RS04760 Protein ID WP_156014146.1
Coordinates 825211..825612 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1869_RS04765 Protein ID WP_156014147.1
Coordinates 825593..825814 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1869_RS04730 (D1869_04770) 820697..821134 - 438 WP_156014140.1 hypothetical protein -
D1869_RS04735 (D1869_04775) 821112..822020 - 909 WP_156014141.1 mechanosensitive ion channel family protein -
D1869_RS04740 (D1869_04780) 822058..822384 - 327 WP_156014142.1 transcriptional regulator -
D1869_RS04745 (D1869_04785) 822454..823113 - 660 WP_156014143.1 ABC transporter ATP-binding protein -
D1869_RS04750 (D1869_04790) 823088..824065 - 978 WP_156014144.1 iron ABC transporter permease -
D1869_RS04755 (D1869_04795) 824154..825122 + 969 WP_231113716.1 ABC transporter substrate-binding protein -
D1869_RS04760 (D1869_04800) 825211..825612 - 402 WP_156014146.1 PIN domain-containing protein Toxin
D1869_RS04765 (D1869_04805) 825593..825814 - 222 WP_156014147.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D1869_RS04770 (D1869_04810) 826012..826680 + 669 WP_184651069.1 RAD55 family ATPase -
D1869_RS04775 (D1869_04815) 826749..827120 + 372 WP_156014149.1 helix-turn-helix domain-containing protein -
D1869_RS04780 (D1869_04820) 827156..827443 + 288 WP_052846426.1 hypothetical protein -
D1869_RS04785 (D1869_04825) 827440..828375 - 936 WP_156014150.1 zinc metalloprotease HtpX -
D1869_RS04790 (D1869_04830) 828404..828901 - 498 WP_156014151.1 DUF2258 domain-containing protein -
D1869_RS04795 (D1869_04835) 829183..829478 - 296 Protein_952 ISH3 family transposase -
D1869_RS04800 (D1869_04840) 829484..829616 + 133 Protein_953 IS6 family transposase -
D1869_RS04805 (D1869_04845) 829849..830280 - 432 WP_156014152.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15420.03 Da        Isoelectric Point: 5.0350

>T141924 WP_156014146.1 NZ_CP045484:c825612-825211 [Sulfurisphaera ohwakuensis]
VEKAIIDTNVIIYDYVEDSEYHKKAEELLDSLNKWIIPAIVIHELVWFLKDMKLEDKINDVFAYVRNEKAEVVCDSVNNI
VDSLEILIREKLPLADYKDMIILSHAIREKLPLVTFDKKLSKIAKKYGVSVVS

Download         Length: 402 bp

>T141924 NZ_CP060240:c4607570-4606815 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATGCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8460.75 Da        Isoelectric Point: 9.6547

>AT141924 WP_156014147.1 NZ_CP045484:c825814-825593 [Sulfurisphaera ohwakuensis]
MERVKVTRNYQITIPASIRNKINLKEGDVLEVYLNGDEIILRKVKSERPRIRLGKKLSPEEIEEAIERGEGNN

Download         Length: 222 bp

>AT141924 NZ_CP060240:c4608073-4607705 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGTTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCACCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References