Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1687511..1688156 Replicon chromosome
Accession NZ_CP045482
Organism Acidianus ambivalens strain LEI 10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1866_RS09600 Protein ID WP_152939415.1
Coordinates 1687767..1688156 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1866_RS09595 Protein ID WP_152939413.1
Coordinates 1687511..1687780 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1866_RS09565 (D1866_09575) 1682618..1683391 - 774 WP_231136308.1 hypothetical protein -
D1866_RS09575 (D1866_09585) 1683620..1684231 + 612 WP_231136309.1 hypothetical protein -
D1866_RS09580 (D1866_09590) 1684333..1685361 - 1029 WP_170254105.1 phospholipase D-like domain-containing protein -
D1866_RS13540 1685871..1686032 + 162 WP_231136310.1 hypothetical protein -
D1866_RS09590 (D1866_09600) 1686096..1687277 - 1182 WP_152939411.1 MFS transporter -
D1866_RS09595 (D1866_09605) 1687511..1687780 + 270 WP_152939413.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D1866_RS09600 (D1866_09610) 1687767..1688156 + 390 WP_152939415.1 type II toxin-antitoxin system VapC family toxin Toxin
D1866_RS09605 (D1866_09615) 1688206..1688829 - 624 WP_152939417.1 type 1 glutamine amidotransferase -
D1866_RS09610 (D1866_09620) 1688884..1689933 - 1050 WP_231136457.1 PLP-dependent aminotransferase family protein -
D1866_RS09615 (D1866_09625) 1689914..1691380 - 1467 WP_152939421.1 APC family permease -
D1866_RS09620 (D1866_09630) 1691584..1692768 + 1185 WP_152939424.1 carboxypeptidase CpsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

SpoVT-AbrB domain

(4-46)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15228.72 Da        Isoelectric Point: 4.5390

>T141923 WP_152939415.1 NZ_CP045482:1687767-1688156 [Acidianus ambivalens]
MIFLDANFIIYLNLGVKEVENFYIKVLQEDRLALDPLVIDEVIYISKKKYNVNFNDTISFLDEVVLPNSLILPIRKEDYD
KAKEIMLQYNLKPSDAFHVAIMLNNSISKIISEDKDFDRIKEIERLWLN

Download         Length: 390 bp

>T141923 NZ_CP060240:3690257-3690835 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10188.84 Da        Isoelectric Point: 5.7527

>AT141923 WP_152939413.1 NZ_CP045482:1687511-1687780 [Acidianus ambivalens]
MTLKVEVGKKGYIIIPKDIRDLLGIKEGDKLILNVYDGKIILEPERKVDINEILKRLEEHHAKISSYAKSAKLGDLLYSS
LEEEFNDFS

Download         Length: 270 bp

>AT141923 NZ_CP060240:3689614-3690168 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References