Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 1572919..1573898 Replicon chromosome
Accession NZ_CP045482
Organism Acidianus ambivalens strain LEI 10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1866_RS09075 Protein ID WP_152939235.1
Coordinates 1573284..1573898 (+) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1866_RS09070 Protein ID WP_152939233.1
Coordinates 1572919..1573266 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1866_RS09030 (D1866_09050) 1567996..1568502 + 507 Protein_1822 U32 family peptidase -
D1866_RS09035 (D1866_09055) 1568517..1568760 - 244 Protein_1823 sulfurtransferase TusA family protein -
D1866_RS09040 (D1866_09060) 1569066..1569794 - 729 WP_152939226.1 hypothetical protein -
D1866_RS09045 (D1866_09065) 1569791..1570833 - 1043 Protein_1825 nitric oxide response protein -
D1866_RS09050 (D1866_09070) 1570881..1571102 - 222 Protein_1826 hemerythrin -
D1866_RS09055 (D1866_09075) 1571199..1572404 + 1206 WP_152939228.1 RNA-guided endonuclease TnpB family protein -
D1866_RS09060 (D1866_09080) 1572414..1572530 - 117 Protein_1828 iron-sulfur cluster assembly protein -
D1866_RS09065 (D1866_09085) 1572620..1572850 + 231 WP_152939231.1 C2H2-type zinc finger protein -
D1866_RS09070 (D1866_09090) 1572919..1573266 + 348 WP_152939233.1 DUF488 domain-containing protein Antitoxin
D1866_RS09075 (D1866_09095) 1573284..1573898 + 615 WP_152939235.1 helix-turn-helix domain-containing protein Toxin
D1866_RS09080 (D1866_09100) 1574001..1575190 + 1190 Protein_1832 AMP-binding protein -
D1866_RS09085 (D1866_09105) 1575200..1575667 - 468 WP_231136301.1 hypothetical protein -
D1866_RS09090 (D1866_09110) 1575667..1575867 - 201 WP_152939237.1 hypothetical protein -
D1866_RS09095 (D1866_09115) 1576207..1577529 + 1323 WP_152939239.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1571199..1572404 1205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23351.51 Da        Isoelectric Point: 9.4506

>T141922 WP_152939235.1 NZ_CP045482:1573284-1573898 [Acidianus ambivalens]
MLKSPFEVTILIEDHPCEVMGVISSTGLKATVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSIKVLKFNDSKVWVKTK
GCSVCKILYSSNVIVEKIKVIKERTLLYTLLVPNTIAFKEFLANLTSQRIKFTVLSIYEISSNDLTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEIMRRALRKVVKYYLDKVG

Download         Length: 615 bp

>T141922 NZ_CP060240:1935514-1936101 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13648.95 Da        Isoelectric Point: 9.9995

>AT141922 WP_152939233.1 NZ_CP045482:1572919-1573266 [Acidianus ambivalens]
MIKIKRVYDPIEKDDGLRVLVDRLWPRGIGKNKVDLWLKDLAPSDELRKRYGHDASKWDEFKRKYFEELDANPKMSILLQ
LIRKGENITLLYASKSPYNNAIALKEYLEKKILKE

Download         Length: 348 bp

>AT141922 NZ_CP060240:1936168-1937022 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References