Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-AbrB |
| Location | 440502..441093 | Replicon | chromosome |
| Accession | NZ_CP045482 | ||
| Organism | Acidianus ambivalens strain LEI 10 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A650CUA9 |
| Locus tag | D1866_RS02620 | Protein ID | WP_013776319.1 |
| Coordinates | 440725..441093 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | D1866_RS02615 | Protein ID | WP_152941269.1 |
| Coordinates | 440502..440741 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D1866_RS02575 (D1866_02555) | 436041..436601 | + | 561 | WP_152941252.1 | isochorismatase family cysteine hydrolase | - |
| D1866_RS02580 | 436593..436766 | - | 174 | WP_152941254.1 | hypothetical protein | - |
| D1866_RS02585 (D1866_02560) | 436773..437339 | - | 567 | WP_152941256.1 | hypothetical protein | - |
| D1866_RS02590 (D1866_02565) | 437355..438041 | - | 687 | WP_152941260.1 | class II glutamine amidotransferase | - |
| D1866_RS13210 | 438059..438178 | - | 120 | WP_231136359.1 | hypothetical protein | - |
| D1866_RS02600 (D1866_02575) | 438314..438637 | + | 324 | WP_155861023.1 | helix-turn-helix domain-containing protein | - |
| D1866_RS02605 (D1866_02580) | 438682..438918 | + | 237 | WP_152941264.1 | hypothetical protein | - |
| D1866_RS02610 (D1866_02590) | 439190..440338 | + | 1149 | WP_152941266.1 | RNA-guided endonuclease TnpB family protein | - |
| D1866_RS02615 (D1866_02595) | 440502..440741 | + | 240 | WP_152941269.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| D1866_RS02620 (D1866_02600) | 440725..441093 | + | 369 | WP_013776319.1 | PIN domain-containing protein | Toxin |
| D1866_RS02625 (D1866_02605) | 441223..441597 | + | 375 | WP_152941271.1 | hypothetical protein | - |
| D1866_RS02630 (D1866_02610) | 441594..441971 | + | 378 | WP_152941273.1 | helix-turn-helix domain-containing protein | - |
| D1866_RS02635 (D1866_02615) | 441983..442240 | + | 258 | WP_231136360.1 | hypothetical protein | - |
| D1866_RS02640 (D1866_02620) | 442240..442683 | + | 444 | WP_152941275.1 | PIN domain-containing protein | - |
| D1866_RS13590 | 443252..443374 | + | 123 | WP_269199639.1 | hypothetical protein | - |
| D1866_RS02645 (D1866_02625) | 443396..443674 | + | 279 | WP_231136361.1 | HEPN domain-containing protein | - |
| D1866_RS02650 (D1866_02630) | 443637..444080 | + | 444 | WP_152941277.1 | nucleotidyltransferase domain-containing protein | - |
| D1866_RS02655 (D1866_02635) | 444168..444536 | + | 369 | WP_152941279.1 | HEPN domain-containing protein | - |
| D1866_RS02660 (D1866_02645) | 444860..445744 | - | 885 | WP_152941281.1 | lysine exporter LysO family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 14266.65 Da Isoelectric Point: 4.8006
>T141921 WP_013776319.1 NZ_CP045482:440725-441093 [Acidianus ambivalens]
MEAVVDTNFIIAVMFKDHVNHDEAIKEWEKLDKVYLPLISITEIAYFLIKHNIDLNVLNEILSDPKIEIIENSVEDISYA
LGKKDEIKSYDDFNDFLILSVAIRQNLPLLTFDKKLKIKMRK
MEAVVDTNFIIAVMFKDHVNHDEAIKEWEKLDKVYLPLISITEIAYFLIKHNIDLNVLNEILSDPKIEIIENSVEDISYA
LGKKDEIKSYDDFNDFLILSVAIRQNLPLLTFDKKLKIKMRK
Download Length: 369 bp
>T141921 NZ_CP060240:c261128-260847 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8730.16 Da Isoelectric Point: 9.7992
>AT141921 WP_152941269.1 NZ_CP045482:440502-440741 [Acidianus ambivalens]
MEEVKVTRNYQITIPYNVREKLGIKIGDKLVVYVEGDKIIIRKKAGNIASLNLTLGKKITDKEINEAINEAGEKIGSGS
MEEVKVTRNYQITIPYNVREKLGIKIGDKLVVYVEGDKIIIRKKAGNIASLNLTLGKKITDKEINEAINEAGEKIGSGS
Download Length: 240 bp
>AT141921 NZ_CP060240:c261352-261125 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|