141920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2697645..2698216 Replicon chromosome
Accession NZ_CP045480
Organism Amycolatopsis sp. YIM 10

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag YIM_RS13090 Protein ID WP_194240317.1
Coordinates 2697866..2698216 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag YIM_RS13085 Protein ID WP_153030612.1
Coordinates 2697645..2697869 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YIM_RS13060 2692723..2693565 - 843 WP_194240140.1 glutamate ABC transporter substrate-binding protein -
YIM_RS13065 2693582..2694310 - 729 WP_194240316.1 amino acid ABC transporter ATP-binding protein -
YIM_RS13070 2694552..2695226 + 675 WP_153030610.1 response regulator transcription factor -
YIM_RS13075 2695230..2696633 + 1404 WP_153030611.1 HAMP domain-containing histidine kinase -
YIM_RS13080 2696623..2697531 - 909 WP_153036955.1 TAXI family TRAP transporter solute-binding subunit -
YIM_RS13085 2697645..2697869 + 225 WP_153030612.1 ribbon-helix-helix protein, CopG family Antitoxin
YIM_RS13090 2697866..2698216 + 351 WP_194240317.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
YIM_RS13095 2698261..2699724 + 1464 WP_153030614.1 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB -
YIM_RS13100 2699721..2700197 + 477 WP_153030615.1 hypothetical protein -
YIM_RS13105 2700229..2700765 + 537 WP_153030616.1 GntR family transcriptional regulator -
YIM_RS13110 2700825..2702159 - 1335 WP_153030617.1 DUF349 domain-containing protein -
YIM_RS13115 2702342..2703043 + 702 WP_153030618.1 class III extradiol dioxygenase subunit B-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12544.67 Da        Isoelectric Point: 11.9341

>T141920 WP_194240317.1 NZ_CP045480:2697866-2698216 [Amycolatopsis sp. YIM 10]
MMRRAEIRLVNFEPARGSESNKTRPAVIVSNDGANVMAGRLGRGVVTVVPVTSNVRRVFPFQVLLPAAECGLAVDSKAQA
EQVRSVSVERIGRRAGKLTPALMERVEAALRLHLGL

Download         Length: 351 bp

>T141920 NZ_CP060211:c714183-713779 [Proteus vulgaris]
ATGATTAAATACCTATTAGATACAAACATCGTTATATTTACCATTAAACGCAGACCTGAATTTTTGCTACCGAAATTCAA
CCAACATGCTGAACAATTAGCTATTTCTACAATCACACTTGCTGAGCTCATTTTTGGTGCTGAAAAAAGTTTAAATTCAG
CTAAAAACTTAGCTACGGTTAACGACTTTGTTTCTCGACTCACTGTTTTATCTTACGATGAGTTAGCCGCTTTTCATTAT
GGGGAAATCAGAGCAACACTTGAAAAACAAGGTAAACGCATTGATGATAATGATTTGCACATAGCTGCACATGCTAGAAG
TAAAGGGCTAATAGTAGTTACAAATAATACTCGAGAATTTGAAAGAGTTGATGGGTTAAGAATTGAGGATTGGACTCATC
ATTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8060.82 Da        Isoelectric Point: 4.0050

>AT141920 WP_153030612.1 NZ_CP045480:2697645-2697869 [Amycolatopsis sp. YIM 10]
MKLSVSLSDEDVAFIDHYAAAADVPSRSAVVHRALELLRASQLEDDYRAAWDEWAALGDEAEWDAATGDGVLAR

Download         Length: 225 bp

>AT141920 NZ_CP060211:c714418-714176 [Proteus vulgaris]
ATGATCCAGCATGGCAAAGTATTTATGAGTAATAGAACACAAAATGTTCGTTTACCCGCTGAGACTCGATTTCCTGATGA
TGTAAAAGAAGTTTTTGTTCGCGTCAAAGGAAAAGAAAGAATAATCACACCGATACAAAATGCTTGGGATAGCTTTTTCT
TATCAGATCAGTCTGTAGCAGATGATTTTTTATCTGAAAGACCAGATCAAGTCACAAGTGAAAGAGAATCCTTTGATGAT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References