141918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2440678..2441454 Replicon chromosome
Accession NZ_CP045472
Organism Staphylococcus aureus strain ZY05

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag GAY69_RS11910 Protein ID WP_000031108.1
Coordinates 2441302..2441454 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag GAY69_RS11905 Protein ID WP_001251218.1
Coordinates 2440678..2441277 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAY69_RS11885 2436594..2438051 + 1458 Protein_2291 ABC transporter permease subunit -
GAY69_RS11890 2438044..2438766 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
GAY69_RS11895 2438917..2440044 + 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
GAY69_RS11900 2440049..2440519 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
GAY69_RS11905 2440678..2441277 + 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
GAY69_RS11910 2441302..2441454 + 153 WP_000031108.1 hypothetical protein Toxin
GAY69_RS11915 2442117..2442512 + 396 WP_000901022.1 hypothetical protein -
GAY69_RS11920 2442708..2444093 + 1386 WP_000116233.1 class II fumarate hydratase -
GAY69_RS11925 2444558..2445379 - 822 WP_000669384.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T141918 WP_000031108.1 NZ_CP045472:2441302-2441454 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T141918 NZ_CP060201:c3059993-3059712 [Pseudomonas protegens]
ATGACTTATAGCCTTGAGTTCCTGCCTTCGGCACACAAGGAATGGAGCAAGTTGGGGCATACGCTTCGAGAGCAATTCAA
GAAAAAGCTCGCCGAACGGCTTGAGGTGCCGCGAATCCCCGCTGATGCCCTGCACGGGCTTCCCGATTGCTACAAAATCA
AACTCAAGGCTTCGGGCTACCGATTGGTTTATCAAGTGATCGAAGAGCGCGTCGTGGTTTGCGTGGTTGCGGTAGGCAAG
CGCGAGCGTGGAACCGTGTACGAGCAGGCCAGGAAACGCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT141918 WP_001251218.1 NZ_CP045472:2440678-2441277 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT141918 NZ_CP060201:c3060228-3059983 [Pseudomonas protegens]
ATGCAGAGTATTCTGGCTGACAAAGCCGTCAGCGTATCTGAGTTGAAGAAAAACCCTTCTGCCGTCTTGAGCGCTGCCCA
GGGCGGGCCAGTGGCGGTGCTGAATCACAACCGTGTCATGGGCTACATGGTTCCGGCCGAGGTTTTCGAAGCGTTGATGG
AACGCCTGGATGATCTGGAGTTGGCCGAAATCGTTCGCGCGCGCAGCCATGAAACGCCCGTTCCGGTCAGTCTGGATGAC
TTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References