Detailed information of TA system TA141917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2288688..2289217
• Replicon: chromosome
• Accession: NZ_CP045472
• Organism: Staphylococcus aureus strain ZY05

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: GAY69_RS11035
• Protein ID: WP_000621175.1
• Coordinates: 2288855..2289217 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: GAY69_RS11030
• Protein ID: WP_000948331.1
• Coordinates: 2288688..2288858 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAY69_RS11000	2283724..2284284	+	561	WP_001092405.1	K(+)-transporting ATPase subunit C	-
GAY69_RS11005	2284493..2284972	+	480	WP_001287083.1	hypothetical protein	-
GAY69_RS11010	2284965..2286548	+	1584	WP_001294642.1	PH domain-containing protein	-
GAY69_RS11015	2286535..2287026	+	492	WP_001205915.1	PH domain-containing protein	-
GAY69_RS11020	2287030..2287389	+	360	WP_000581194.1	holo-ACP synthase	-
GAY69_RS11025	2287455..2288603	+	1149	WP_001280702.1	alanine racemase	-
GAY69_RS11030	2288688..2288858	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
GAY69_RS11035	2288855..2289217	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
GAY69_RS11040	2289567..2290568	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
GAY69_RS11045	2290687..2291013	+	327	WP_001052491.1	anti-sigma factor antagonist	-
GAY69_RS11050	2291015..2291494	+	480	WP_001190825.1	anti-sigma B factor RsbW	-
GAY69_RS11055	2291469..2292239	+	771	WP_001041107.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T141917 WP_000621175.1 NZ_CP045472:2288855-2289217 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T141917 NZ_CP060201:c2955430-2955248 [Pseudomonas protegens]
ATGCGCAGTCGGGAGATGATCGGCAAGATCGAGGCGGATGGTTGGTACCTGATCGCCGTGAAGGGCAGTCACCATCAGTA
CAAGCATCCCTGGAAGCCAGGGCGCGTCACCATCAGGCACCCGGATGCGGATCTGCCCCGGGGCACGATCAACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT141917 WP_000948331.1 NZ_CP045472:2288688-2288858 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT141917 NZ_CP060201:c2955251-2954817 [Pseudomonas protegens]
ATGAGTCCGTTATTGCATGAGGAGTCCAACGACATGAAATTCCCGGTGGTTCTGCACAAGGATGCCGACTCCGAATACGG
GGTGATCGTTCCGGATGTGCCGGGCTGTTACTCCGCCGGCCAGACCGTGTCCCAGGCGTTCGAAAACGTGAAGCAGGCGC
TGTCTCTGCATTACGAAGGATTGGTGGCCGATGGCGAGCCCCTGCCGCAGGTGCACGAAATCGATGATCACCTGGATAAC
CCCGACTACGCCGGGGGCGTATGGGGCGTGGTGGAGTTCGACGTGACGCCGTATTTCGGCAAGTCGGTGCGCTTCAATGC
CACCCTGCCCGAGCACCTGCTGGAGCGCATCGATCAGACGGTCAAGCGTGACCAGCGCTACAACTCGCGTTCCGGGTTCC
TGGCCGCCGCAGCGCTGCGCGAACTGTCGGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1