Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2268963..2269477 Replicon chromosome
Accession NZ_CP045472
Organism Staphylococcus aureus strain ZY05

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag GAY69_RS10945 Protein ID WP_000581792.1
Coordinates 2269268..2269477 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag GAY69_RS10940 Protein ID WP_000138934.1
Coordinates 2268963..2269256 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAY69_RS10905 2264224..2264865 + 642 WP_000483147.1 thiamine phosphate synthase -
GAY69_RS10910 2264951..2265823 + 873 WP_000725802.1 membrane protein insertase YidC -
GAY69_RS10930 2266638..2267285 - 648 WP_001187610.1 HD domain-containing protein -
GAY69_RS10935 2267313..2268797 - 1485 WP_000571549.1 cardiolipin synthase -
GAY69_RS10940 2268963..2269256 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
GAY69_RS10945 2269268..2269477 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
GAY69_RS10950 2269605..2269742 + 138 WP_000828354.1 hypothetical protein -
GAY69_RS10955 2270006..2271208 - 1203 WP_001109939.1 rod shape-determining protein RodA -
GAY69_RS10960 2271526..2272596 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
GAY69_RS10965 2272611..2273969 + 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T141916 WP_000581792.1 NZ_CP045472:2269268-2269477 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T141916 NZ_CP060201:2516100-2516390 [Pseudomonas protegens]
ATGCACACCCCAGTCACCCGCTTCGACGCAGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACGCCGGCGACGGCAAGCTGATCCGCGCCGCGCTCAACGACATCGCTCGCGCCCGCGGCATGACCCAGG
TCGCCCGCGACACCGGCCTGGGCCGTGAGAGCCTTTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCGACTATC
ATCAAGGTCATGAAGGCGCTCGGGCTCAAGCTCAACGTCAGCCCGGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT141916 WP_000138934.1 NZ_CP045472:2268963-2269256 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT141916 NZ_CP060201:2515794-2516096 [Pseudomonas protegens]
ATGTTCATCTTTGAGCAGACTCAGGCGTTCACCCACTGGCTGCTACGCCTTAAAGATCCCCAGGGAAAAACCCGCGTGCT
GGCGCGGATCAGGGCCGCGCAACTGGGCCGGTTCGGCGACTGCGAACCCGTGGGCGATGGGGTCTATGAAATGCGCATCC
ACCGTGGCCCCGGCTACCGGGTGTACTTTTCGCGCCGGGGCAATCGGATCTACCTGTTGCTGATCGGCGGCGACAAAAGC
ACCCAGAAACGCGATATCCAACAGGCCAGGCAACTGGCCCACGACCTCAAGAGCGAGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References