Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 705663..706140 Replicon chromosome
Accession NZ_CP045472
Organism Staphylococcus aureus strain ZY05

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag GAY69_RS03380 Protein ID WP_000052076.1
Coordinates 705952..706140 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag GAY69_RS03375 Protein ID WP_001059690.1
Coordinates 705663..705923 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAY69_RS03340 701055..701771 - 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -
GAY69_RS03345 701919..702341 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
GAY69_RS03350 702740..703234 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
GAY69_RS03355 703390..704007 + 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
GAY69_RS03360 704080..704661 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
GAY69_RS03365 704886..705122 + 237 WP_000368687.1 hypothetical protein -
GAY69_RS03370 705119..705322 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
GAY69_RS03375 705663..705923 + 261 WP_001059690.1 hypothetical protein Antitoxin
GAY69_RS03380 705952..706140 + 189 WP_000052076.1 hypothetical protein Toxin
GAY69_RS03385 706328..706897 + 570 WP_001106657.1 hypothetical protein -
GAY69_RS03390 706985..707269 + 285 WP_001004397.1 hypothetical protein -
GAY69_RS03395 707331..707549 + 219 WP_000005888.1 hypothetical protein -
GAY69_RS03400 708048..708248 - 201 WP_001059082.1 cold-shock protein -
GAY69_RS03405 708605..709291 - 687 WP_001823812.1 thermonuclease family protein -
GAY69_RS03410 709632..710102 - 471 WP_000824462.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb / selq / selk / vWbp 678114..720294 42180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T141907 WP_000052076.1 NZ_CP045472:705952-706140 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T141907 NZ_CP060192:c2608232-2607486 [Bacillus sp. PAMC28748]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTTATTGTTTTGGCGCTGGCTCTGTACGTAGCTGCCGTGTGGCGTTTTGA
AAAACAGCTCGCCGAAAAAACGGTCGCCATCAGAAAAACGTGGTACCTTCTTTATGTCATCGGCGCCGTGATATATTGGA
CGCACGATCCGCAGTCAATTTTCACAAACCCGCTTCATTACCTGATCGTTGCCGTTTTTTTCACGTTGACAGACGCTTTT
ATTTTCTTAAATGCCTACTTTAAAAAGCTCGGCAGCTCTGAACTCGCGACAGATACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACGTATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGCATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAAGATCATTTGCTTGAGCATATGGAAAACCGGTTCGATGTTCAAGAAAAGCTTGA
CCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGATTATCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACGACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT141907 WP_001059690.1 NZ_CP045472:705663-705923 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT141907 NZ_CP060192:c2607486-2607313 [Bacillus sp. PAMC28748]
ATGGAGCCTGCTTTTCAGCAAGACCAGGAAAGCGTAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAGGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References