Detailed information of TA system TA141906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 687914..688446
• Replicon: chromosome
• Accession: NZ_CP045472
• Organism: Staphylococcus aureus strain ZY05

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: GAY69_RS03230
• Protein ID: WP_001103942.1
• Coordinates: 687914..688234 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: GAY69_RS03235
• Protein ID: WP_001058486.1
• Coordinates: 688237..688446 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAY69_RS03200	683065..683406	-	342	WP_001190615.1	hypothetical protein	-
GAY69_RS03205	683923..684564	-	642	WP_001019764.1	hypothetical protein	-
GAY69_RS03210	684561..684845	-	285	WP_000998181.1	hypothetical protein	-
GAY69_RS03215	684847..685209	-	363	WP_001039168.1	hypothetical protein	-
GAY69_RS03220	685495..686964	-	1470	WP_000390454.1	virulence-associated E family protein	-
GAY69_RS03225	686981..687850	-	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
GAY69_RS03230	687914..688234	-	321	WP_001103942.1	DUF1474 family protein	Toxin
GAY69_RS03235	688237..688446	-	210	WP_001058486.1	hypothetical protein	Antitoxin
GAY69_RS03240	688439..688585	-	147	WP_000784875.1	hypothetical protein	-
GAY69_RS03245	688597..688869	-	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
GAY69_RS03250	688885..689124	-	240	WP_112368207.1	helix-turn-helix domain-containing protein	-
GAY69_RS03255	689317..689649	+	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
GAY69_RS03260	689661..690119	+	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
GAY69_RS03265	690136..690567	+	432	WP_001228759.1	hypothetical protein	-
GAY69_RS03270	690637..691365	+	729	WP_001033318.1	staphylococcal enterotoxin type Q	-
GAY69_RS03275	691389..692117	+	729	WP_000733774.1	staphylococcal enterotoxin type K	-
GAY69_RS03280	692205..693425	+	1221	WP_000266157.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / selq / selk / vWbp	678114..720294	42180

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T141906 WP_001103942.1 NZ_CP045472:c688234-687914 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T141906 NZ_CP060192:1773367-1773717 [Bacillus sp. PAMC28748]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT141906 WP_001058486.1 NZ_CP045472:c688446-688237 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT141906 NZ_CP060192:1773081-1773362 [Bacillus sp. PAMC28748]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: Q93CD4