Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 841149..841626 Replicon chromosome
Accession NZ_CP045468
Organism Staphylococcus aureus strain SAW1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag GBR75_RS03945 Protein ID WP_000052076.1
Coordinates 841149..841337 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag GBR75_RS03950 Protein ID WP_001059690.1
Coordinates 841366..841626 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBR75_RS03915 837187..837657 + 471 WP_000824462.1 hypothetical protein -
GBR75_RS03920 837998..838684 + 687 WP_001823812.1 thermonuclease family protein -
GBR75_RS03925 839041..839241 + 201 WP_001059082.1 cold-shock protein -
GBR75_RS03930 839740..839958 - 219 WP_000005888.1 hypothetical protein -
GBR75_RS03935 840020..840304 - 285 WP_001004397.1 hypothetical protein -
GBR75_RS03940 840392..840961 - 570 WP_001106657.1 hypothetical protein -
GBR75_RS03945 841149..841337 - 189 WP_000052076.1 hypothetical protein Toxin
GBR75_RS03950 841366..841626 - 261 WP_001059690.1 hypothetical protein Antitoxin
GBR75_RS03955 841967..842170 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
GBR75_RS03960 842167..842403 - 237 WP_000368687.1 hypothetical protein -
GBR75_RS03965 842627..843208 + 582 WP_193561544.1 phosphoglycerate mutase family protein -
GBR75_RS03970 843281..843898 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
GBR75_RS03975 844054..844548 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
GBR75_RS03980 844947..845369 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
GBR75_RS03985 845517..846233 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selk / selq / seb / seb 835829..868863 33034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Cro/C1-type helix-turn-helix domain

(50-93)

Antitoxin

Toxin HigB-like

(13-85)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T141891 WP_000052076.1 NZ_CP045468:c841337-841149 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T141891 NZ_CP060159:1158320-1158625 [Xylella fastidiosa subsp. fastidiosa]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT141891 WP_001059690.1 NZ_CP045468:c841626-841366 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT141891 NZ_CP060159:1158020-1158316 [Xylella fastidiosa subsp. fastidiosa]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATCTCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References