Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 39171..39718 Replicon plasmid pSal-3973_DHA_CMY
Accession NZ_CP045467
Organism Salmonella enterica subsp. enterica serovar Anatum strain Sal-3973

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag GER12_RS22615 Protein ID WP_000970007.1
Coordinates 39437..39718 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag GER12_RS22610 Protein ID WP_000079941.1
Coordinates 39171..39440 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GER12_RS22585 34689..34877 - 189 Protein_43 IS91 family transposase -
GER12_RS22590 34989..35294 - 306 WP_001255015.1 LysR family transcriptional regulator -
GER12_RS22595 35322..36536 - 1215 WP_023300759.1 chloramphenicol/florfenicol efflux MFS transporter FloR -
GER12_RS23655 36753..37199 - 447 Protein_46 DUF3363 domain-containing protein -
GER12_RS22605 37668..38813 - 1146 Protein_47 IS91-like element ISVsa3 family transposase -
GER12_RS22610 39171..39440 + 270 WP_000079941.1 hypothetical protein Antitoxin
GER12_RS22615 39437..39718 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GER12_RS22620 39758..40606 + 849 WP_021265674.1 3'-5' exonuclease -
GER12_RS22625 40723..41196 + 474 WP_001334658.1 hypothetical protein -
GER12_RS23660 41673..41939 - 267 WP_000955263.1 hypothetical protein -
GER12_RS22630 41939..42433 - 495 WP_001459505.1 hypothetical protein -
GER12_RS22635 42489..43091 - 603 WP_000517695.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..195486 195486


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-99)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T141889 WP_000970007.1 NZ_CP045467:39437-39718 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T141889 NZ_CP060159:457763-458065 [Xylella fastidiosa subsp. fastidiosa]
ATGGAGAAAGGCACATCTCACTATAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTCGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT141889 WP_000079941.1 NZ_CP045467:39171-39440 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT141889 NZ_CP060159:458068-458469 [Xylella fastidiosa subsp. fastidiosa]
ATGAGATGTCCATGCTGCGGCGCGGCAGAACTGATCCACGACACGCGCGACATGCTTTACACCTACAAGAGCGAAACTAC
TAGTATCCCAACGGTGACCGGCGACTTCTGCCCGGCTTGTGGCGAAGTCGTCTTGGACCGTGAACATGGTGATCGTTACA
GCGAATTGGTCGGCTTGTTCCAACGTCAGGTGAATTCGGCCTACGTCGATCCTGGTTACATTACCAAGGTACGCCGGAAG
CTTGATCTCGACCAGCGGCAAGCTGCCGAACTGTTCGGTGGTGGTGTTAATGCTTTCTCACGTTACGAGAACGGTAAAAC
CAAGCCGCCGCTGTCTTTGGTTAAGTTATTCAAGCTTCTGGATCGCCACCCCGATTTGCTCAACGAAGTGAAGAGTTCCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References