Detailed information of TA system TA141887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/MqsA(antitoxin)
• Location: 4793..5258
• Replicon: plasmid pM-3471_MCR33k
• Accession: NZ_CP045460
• Organism: Salmonella enterica subsp. enterica serovar Anatum strain M-3471

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: U9ZUY2
• Locus tag: GER29_RS22875
• Protein ID: WP_001230707.1
• Coordinates: 5007..5258 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: M7CCF8
• Locus tag: GER29_RS22870
• Protein ID: WP_000801440.1
• Coordinates: 4793..5020 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GER29_RS22830	23..238	-	216	WP_000760375.1	EexN family lipoprotein	-
GER29_RS22835	235..528	-	294	WP_060598542.1	LuxR family transcriptional regulator	-
GER29_RS22840	605..1834	-	1230	WP_165890934.1	relaxase/mobilization nuclease domain-containing protein	-
GER29_RS22845	1838..2341	-	504	WP_000781813.1	hypothetical protein	-
GER29_RS22850	2702..3049	-	348	WP_000681613.1	type II toxin-antitoxin system HicB family antitoxin	-
GER29_RS22855	3046..3294	-	249	WP_000520549.1	type II toxin-antitoxin system HicA family toxin	-
GER29_RS22860	3599..3949	-	351	WP_000854259.1	hypothetical protein	-
GER29_RS22865	4040..4339	-	300	WP_000650309.1	hypothetical protein	-
GER29_RS22870	4793..5020	-	228	WP_000801440.1	hypothetical protein	Antitoxin
GER29_RS22875	5007..5258	-	252	WP_001230707.1	hypothetical protein	Toxin
GER29_RS22880	5255..5797	-	543	WP_001083906.1	hypothetical protein	-
GER29_RS22885	5902..6417	-	516	WP_001025395.1	J domain-containing protein	-
GER29_RS22890	7832..8698	+	867	WP_001353743.1	replication initiation protein	-
GER29_RS22895	8711..9115	+	405	WP_012421203.1	hypothetical protein	-
GER29_RS22900	9250..9777	+	528	WP_000577043.1	DUF2726 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..33309	33309

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>T141887 WP_001230707.1 NZ_CP045460:c5258-5007 [Salmonella enterica subsp. enterica serovar Anatum]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>T141887 NZ_CP060159:457108-457389 [Xylella fastidiosa subsp. fastidiosa]
ATGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCTCAAGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCCAAGCGCCCCGAAGATATGAATGCTCCAGGCTGGAAACTGC
ACCCACTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTGAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 11203.44 Da
• Isoelectric Point: 5.5500

>AT141887 WP_000801440.1 NZ_CP045460:c5020-4793 [Salmonella enterica subsp. enterica serovar Anatum]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 228 bp

>AT141887 NZ_CP060159:457400-457675 [Xylella fastidiosa subsp. fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Structures

Toxin

• AlphaFold DB: U9ZUY2

Antitoxin

• AlphaFold DB: A0A5Y6U8W9