Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2702..3294 Replicon plasmid pM-3471_MCR33k
Accession NZ_CP045460
Organism Salmonella enterica subsp. enterica serovar Anatum strain M-3471

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag GER29_RS22855 Protein ID WP_000520549.1
Coordinates 3046..3294 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag GER29_RS22850 Protein ID WP_000681613.1
Coordinates 2702..3049 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GER29_RS22830 23..238 - 216 WP_000760375.1 EexN family lipoprotein -
GER29_RS22835 235..528 - 294 WP_060598542.1 LuxR family transcriptional regulator -
GER29_RS22840 605..1834 - 1230 WP_165890934.1 relaxase/mobilization nuclease domain-containing protein -
GER29_RS22845 1838..2341 - 504 WP_000781813.1 hypothetical protein -
GER29_RS22850 2702..3049 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GER29_RS22855 3046..3294 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
GER29_RS22860 3599..3949 - 351 WP_000854259.1 hypothetical protein -
GER29_RS22865 4040..4339 - 300 WP_000650309.1 hypothetical protein -
GER29_RS22870 4793..5020 - 228 WP_000801440.1 hypothetical protein -
GER29_RS22875 5007..5258 - 252 WP_001230707.1 hypothetical protein -
GER29_RS22880 5255..5797 - 543 WP_001083906.1 hypothetical protein -
GER29_RS22885 5902..6417 - 516 WP_001025395.1 J domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33309 33309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 12233.67 Da        Isoelectric Point: 5.5500

>T141886 WP_000520549.1 NZ_CP045460:c3294-3046 [Salmonella enterica subsp. enterica serovar Anatum]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFF

Download         Length: 249 bp

>T141886 NZ_CP060156:c1741399-1741220 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 17090.50 Da        Isoelectric Point: 5.5500

>AT141886 WP_000681613.1 NZ_CP045460:c3049-2702 [Salmonella enterica subsp. enterica serovar Anatum]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 348 bp

>AT141886 NZ_CP060156:c1741183-1740731 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References