141883

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4561843..4562438 Replicon chromosome
Accession NZ_CP045457
Organism Escherichia coli strain ET12567

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag ECET_RS22115 Protein ID WP_000239577.1
Coordinates 4562088..4562438 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag ECET_RS22110 Protein ID WP_001223208.1
Coordinates 4561843..4562094 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECET_RS22100 4557508..4561287 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
ECET_RS22105 4561290..4561631 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
ECET_RS22110 4561843..4562094 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
ECET_RS22115 4562088..4562438 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
ECET_RS22120 4562518..4563048 - 531 WP_000055075.1 inorganic diphosphatase -
ECET_RS22125 4563358..4564314 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
ECET_RS22130 4564454..4565956 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
ECET_RS22135 4565970..4566992 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T141883 WP_000239577.1 NZ_CP045457:4562088-4562438 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T141883 NZ_CP060141:2839641-2839829 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT141883 WP_001223208.1 NZ_CP045457:4561843-4562094 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT141883 NZ_CP060141:2839352-2839612 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References