141878

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3114724..3115378 Replicon chromosome
Accession NZ_CP045457
Organism Escherichia coli strain ET12567

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag ECET_RS15170 Protein ID WP_000244777.1
Coordinates 3114724..3115131 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag ECET_RS15175 Protein ID WP_000354046.1
Coordinates 3115112..3115378 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECET_RS15150 3110681..3112414 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
ECET_RS15155 3112420..3113130 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECET_RS15160 3113155..3114051 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
ECET_RS15165 3114163..3114684 + 522 WP_001055874.1 flavodoxin FldB -
ECET_RS15170 3114724..3115131 - 408 WP_000244777.1 toxin CptA Toxin
ECET_RS15175 3115112..3115378 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
ECET_RS15180 3115621..3116601 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
ECET_RS15185 3116797..3117456 - 660 WP_000250274.1 hemolysin III family protein -
ECET_RS15190 3117620..3117931 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
ECET_RS15195 3117976..3119409 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
ECET_RS15200 3119466..3120209 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T141878 WP_000244777.1 NZ_CP045457:c3115131-3114724 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T141878 NZ_CP060141:1559843-1560205 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT141878 WP_000354046.1 NZ_CP045457:c3115378-3115112 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT141878 NZ_CP060141:1559676-1559846 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References