141876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2843396..2844063 Replicon chromosome
Accession NZ_CP045457
Organism Escherichia coli strain ET12567

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag ECET_RS13895 Protein ID WP_001094400.1
Coordinates 2843734..2844063 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag ECET_RS13890 Protein ID WP_000072690.1
Coordinates 2843396..2843713 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECET_RS13860 2838448..2839457 - 1010 Protein_2710 arsenic transporter -
ECET_RS13865 2839599..2841302 + 1704 WP_001698958.1 hypothetical protein -
ECET_RS13870 2841874..2842097 + 224 Protein_2712 DUF905 family protein -
ECET_RS13875 2842200..2842658 + 459 WP_000211841.1 antirestriction protein -
ECET_RS13880 2842667..2843149 + 483 WP_001407480.1 RadC family protein -
ECET_RS13885 2843158..2843358 + 201 WP_001395452.1 DUF987 domain-containing protein -
ECET_RS13890 2843396..2843713 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECET_RS13895 2843734..2844063 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
ECET_RS13900 2844427..2848167 - 3741 Protein_2718 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T141876 WP_001094400.1 NZ_CP045457:2843734-2844063 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T141876 NZ_CP060141:1483011-1483115 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT141876 WP_000072690.1 NZ_CP045457:2843396-2843713 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT141876 NZ_CP060141:c1483273-1483110 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References