Detailed information of TA system TA141864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 1751490..1752128
• Replicon: chromosome
• Accession: NZ_CP045457
• Organism: Escherichia coli strain ET12567

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S1F9G9
• Locus tag: ECET_RS08635
• Protein ID: WP_000813794.1
• Coordinates: 1751952..1752128 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ECET_RS08630
• Protein ID: WP_001270286.1
• Coordinates: 1751490..1751906 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECET_RS08610	1746642..1747583	-	942	WP_001251304.1	ABC transporter permease	-
ECET_RS08615	1747584..1748597	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
ECET_RS08620	1748615..1749760	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
ECET_RS08625	1750005..1751411	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
ECET_RS08630	1751490..1751906	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
ECET_RS08635	1751952..1752128	-	177	WP_000813794.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
ECET_RS08640	1752350..1752580	+	231	WP_000494244.1	YncJ family protein	-
ECET_RS08645	1752672..1754633	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
ECET_RS08650	1754706..1755242	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
ECET_RS08655	1755295..1756509	+	1215	WP_001326689.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6749.83 Da
• Isoelectric Point: 11.2298

>T141864 WP_000813794.1 NZ_CP045457:c1752128-1751952 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T141864 NZ_CP060136:c8396-8115 [Salmonella enterica subsp. enterica serovar London]
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Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT141864 WP_001270286.1 NZ_CP045457:c1751906-1751490 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT141864 NZ_CP060136:c8637-8386 [Salmonella enterica subsp. enterica serovar London]
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Structures

Toxin

• PDB: 6HPB