Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1611528..1612054 | Replicon | chromosome |
| Accession | NZ_CP045457 | ||
| Organism | Escherichia coli strain ET12567 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | ECET_RS07935 | Protein ID | WP_000323025.1 |
| Coordinates | 1611767..1612054 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | ECET_RS07930 | Protein ID | WP_000534858.1 |
| Coordinates | 1611528..1611767 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECET_RS07870 | 1606555..1607322 | - | 768 | Protein_1536 | exonuclease | - |
| ECET_RS07875 | 1607415..1607606 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| ECET_RS07880 | 1607603..1607791 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| ECET_RS07890 | 1608359..1608577 | - | 219 | WP_001171942.1 | hypothetical protein | - |
| ECET_RS07895 | 1608737..1608892 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| ECET_RS07900 | 1609059..1609466 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| ECET_RS07905 | 1609550..1609780 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| ECET_RS07910 | 1609764..1610042 | + | 279 | Protein_1543 | hypothetical protein | - |
| ECET_RS07915 | 1610077..1610226 | + | 150 | WP_011443592.1 | hypothetical protein | - |
| ECET_RS07920 | 1610663..1610995 | - | 333 | WP_001301033.1 | protein FlxA | - |
| ECET_RS07925 | 1611198..1611503 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| ECET_RS07930 | 1611528..1611767 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| ECET_RS07935 | 1611767..1612054 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| ECET_RS07940 | 1612126..1612281 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| ECET_RS07945 | 1612498..1612749 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| ECET_RS07950 | 1612816..1613094 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| ECET_RS07955 | 1613096..1614145 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| ECET_RS07960 | 1614159..1614911 | + | 753 | WP_001047135.1 | antitermination protein | - |
| ECET_RS07965 | 1615189..1615278 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| ECET_RS07970 | 1615333..1615545 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| ECET_RS07975 | 1615846..1616061 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| ECET_RS07980 | 1616815..1617030 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1599530..1637411 | 37881 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T141862 WP_000323025.1 NZ_CP045457:1611767-1612054 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T141862 NZ_CP060131:c772497-772093 [Pseudonocardia sp. CGMCC 4.1532]
GTGACGACCCACCTCCTGGACGCGGACGTGCTGATCGCACTCACGGTCGCCGACCACGAGCACCACGCGCGGGCGTCCGC
CTGGGCGGCCGGGATCGGGGAGTTCGCGGTCTGCCCCGTGGTGGAGGGGGCGCTGGTCCGCTTCCTGGTCCGTGTGGGGG
AGAGCGCCGCGGTGGCGCAGCAGGTGCTCCGTGCGGTGCACGCCCTGCCCGGCTGCGTGCTCTGGCCGGACTCGCTGTCC
TACGCCGCGGCGGATCTGTCCCGCGTCCGCGGCCACCGGCAGGTCACCGACGCCTACCTCGTGGGCCTCGTCGCCGCGCG
CTCCGACGCCCTGCTGGCGACCCTGGACGAGGGGTTGGCGCAGTCGCACCCGGAACTGGCGCTGCTGGTCCCCGCCGCGC
CGTGA
GTGACGACCCACCTCCTGGACGCGGACGTGCTGATCGCACTCACGGTCGCCGACCACGAGCACCACGCGCGGGCGTCCGC
CTGGGCGGCCGGGATCGGGGAGTTCGCGGTCTGCCCCGTGGTGGAGGGGGCGCTGGTCCGCTTCCTGGTCCGTGTGGGGG
AGAGCGCCGCGGTGGCGCAGCAGGTGCTCCGTGCGGTGCACGCCCTGCCCGGCTGCGTGCTCTGGCCGGACTCGCTGTCC
TACGCCGCGGCGGATCTGTCCCGCGTCCGCGGCCACCGGCAGGTCACCGACGCCTACCTCGTGGGCCTCGTCGCCGCGCG
CTCCGACGCCCTGCTGGCGACCCTGGACGAGGGGTTGGCGCAGTCGCACCCGGAACTGGCGCTGCTGGTCCCCGCCGCGC
CGTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT141862 WP_000534858.1 NZ_CP045457:1611528-1611767 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT141862 NZ_CP060131:c772724-772494 [Pseudonocardia sp. CGMCC 4.1532]
GTGCGCACCACCGTCGACCTCCCCCCGGCCGTGCACCGGCGCGCCCAGGAGATCGCCAAGCGCCGAGGACTCTCGCTGTC
GGCCGTGGTCGCCGAGCTCACCGTCCGCGGCCTGGCCCAGCTCGGCGAGCCGGTGGTGATCGGCACCGACGAGCGCTCCG
GGTTCCCGGTCGTCACGATCGGCCGTCGGGTCACCTCGGAGCAGGTCGCCGCCGCGCTGGACGAGGAGTGA
GTGCGCACCACCGTCGACCTCCCCCCGGCCGTGCACCGGCGCGCCCAGGAGATCGCCAAGCGCCGAGGACTCTCGCTGTC
GGCCGTGGTCGCCGAGCTCACCGTCCGCGGCCTGGCCCAGCTCGGCGAGCCGGTGGTGATCGGCACCGACGAGCGCTCCG
GGTTCCCGGTCGTCACGATCGGCCGTCGGGTCACCTCGGAGCAGGTCGCCGCCGCGCTGGACGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|