Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 2698980..2699539 Replicon chromosome
Accession NZ_CP045456
Organism Brevundimonas sp. Bb-A

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0D782
Locus tag BSP_RS13230 Protein ID WP_054766147.1
Coordinates 2699207..2699539 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0P0CRE5
Locus tag BSP_RS13225 Protein ID WP_054766146.1
Coordinates 2698980..2699210 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSP_RS13205 2694619..2695272 - 654 WP_054766143.1 squalene/phytoene synthase family protein -
BSP_RS13210 2695262..2696278 - 1017 WP_152950621.1 polyprenyl synthetase family protein -
BSP_RS13215 2696403..2697158 + 756 WP_054766144.1 methyltransferase -
BSP_RS13220 2697288..2698955 + 1668 WP_054766145.1 energy-dependent translational throttle protein EttA -
BSP_RS13225 2698980..2699210 + 231 WP_054766146.1 DUF433 domain-containing protein Antitoxin
BSP_RS13230 2699207..2699539 + 333 WP_054766147.1 DUF5615 family PIN-like protein Toxin
BSP_RS13235 2699536..2700462 + 927 WP_152950622.1 2-hydroxyacid dehydrogenase -
BSP_RS13240 2700463..2700867 - 405 WP_194166968.1 EF-hand domain-containing protein -
BSP_RS13245 2700985..2701959 + 975 WP_152950624.1 metalloregulator ArsR/SmtB family transcription factor -
BSP_RS13250 2701956..2702912 + 957 WP_152950625.1 methylenetetrahydrofolate reductase [NAD(P)H] -
BSP_RS13255 2702912..2704006 + 1095 WP_152950626.1 homocysteine S-methyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(2-77)

Antitoxin

Protein of unknown function DUF433

(9-64)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12615.58 Da        Isoelectric Point: 7.4063

>T141853 WP_054766147.1 NZ_CP045456:2699207-2699539 [Brevundimonas sp. Bb-A]
VKFIVDAQLPIALADWLRANGHAADHVSTLLAVHARDQDIWDLARAESRVIITKDRDFAIWAADRRLGPQIVWLRLGNAT
RRVLIEWLEPRWARIEQGLLDGLHLIEVRA

Download         Length: 333 bp

>T141853 NZ_CP060122:3898114-3898503 [Sphingobium yanoikuyae]
ATGATCCTTGATACATCGGCGCTGGTTGCGATCCTTTATCGCGAACCCGAAGCGGAATCGTTTACCCAGGCAATCCACAA
TGCCGACGCATGCCGTATCAGCGGCGCAACCTATGTCGAATTGTCGATCGTCATTGAAAACCAGCTCGGATCCGAAGGAA
TGCGCCAGGCAGAAGCCTTCTTCCGGCGCGCGGGAATTACGATCGAACCGGTGACGGTCGAACATGGTGAGTTGGCGCGG
CAAGCCTTTCTGGATTTCGGCAAGGGCCGCCACAAGGCCGGCTTGAATTTCGGCGACTGCTTTTCATTTGCACTCGCCAA
GGCGACCGGCGAGCCCTTGCTGTTCAAGGGCAATGACTTTGCCCTGACAGATCTCGAGGCGGCTGCATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 7983.07 Da        Isoelectric Point: 3.9918

>AT141853 WP_054766146.1 NZ_CP045456:2698980-2699210 [Brevundimonas sp. Bb-A]
MSDDLLSRITIDPSQCGGRPCIRGMRIRVQDVLDMLAGGASPEEVLADFPYLEADDIRASLAYAAASIGDTGVIAA

Download         Length: 231 bp

>AT141853 NZ_CP060122:3897869-3898117 [Sphingobium yanoikuyae]
GTGAGCCTTAACGTCAAAGATCCCGAGGCTCATAGACTCGCCCGTGCCATCGCCCAGGCGACCGGCCAGAGCATGACCCG
CGTGGTGACGGAGGCGCTGCGCGAGTGCTACGCCCGGATCGAGCGGAACAAACGCAAGGCAAGCGTGGCGGAGCTGCTGG
CAATCGCGGATCGCGCCGCCGTCCATGTGAAGCGATCCTATATCGAGCATGGCGAGCTGCTTTACGATGAAAATGGCTTG
CCGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0D782

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0CRE5

References