Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 991080..991741 Replicon chromosome
Accession NZ_CP045456
Organism Brevundimonas sp. Bb-A

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0DC47
Locus tag BSP_RS04910 Protein ID WP_054764716.1
Coordinates 991080..991517 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0P0DI52
Locus tag BSP_RS16175 Protein ID WP_054764717.1
Coordinates 991514..991741 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSP_RS04880 986568..986999 + 432 WP_152949492.1 hypothetical protein -
BSP_RS04885 987035..988132 + 1098 WP_152949493.1 helix-turn-helix domain-containing protein -
BSP_RS04890 988191..988904 + 714 WP_152949494.1 CPBP family intramembrane metalloprotease -
BSP_RS04895 989031..989786 + 756 WP_152949495.1 protein TolQ -
BSP_RS04900 989790..990245 + 456 WP_152949496.1 protein TolR -
BSP_RS04905 990246..991076 + 831 WP_152949497.1 hypothetical protein -
BSP_RS04910 991080..991517 - 438 WP_054764716.1 DNA-binding protein Toxin
BSP_RS16175 991514..991741 - 228 WP_054764717.1 hypothetical protein Antitoxin
BSP_RS04915 991886..993259 + 1374 WP_152949498.1 Tol-Pal system protein TolB -
BSP_RS04920 993413..993970 + 558 WP_152949499.1 peptidoglycan-associated lipoprotein Pal -
BSP_RS04925 994084..995193 + 1110 WP_152949500.1 DUF3667 domain-containing protein -
BSP_RS04930 995236..996078 + 843 WP_152949501.1 tol-pal system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15967.30 Da        Isoelectric Point: 6.9782

>T141851 WP_054764716.1 NZ_CP045456:c991517-991080 [Brevundimonas sp. Bb-A]
MTYLLDVNVLIALVDPRHVFHHPANTWFQREAAPSWATCPITENGLVRIVGSSRYRNPVGPPSDVVRILALLRDMAGHVF
WPDAVSLADERLFEPSALTKPEQITDAYLLALAVSNGGRLATFDRRLSPDAVKGGRSALHLITDT

Download         Length: 438 bp

>T141851 NZ_CP060122:2460292-2460693 [Sphingobium yanoikuyae]
ATGTTCCTGCTCGATACGAATATCCTGTCGGACCTGATCCGACAGCCCGATGGCATGGTCGCCCACGCTATCGCCGACGT
CGGCGAGGACGCGGTTGCGACCAGCATCATCGTTGCCGGCGAACTGCGCTATGGCGCAGAAAAGCGCGGATCGCCGCGCC
TGAAAAGCAAGATCGAGGATTTGCTGTCTCTCATTGCAGTGCTGCCGCTCAAGGACGATGCCGACGCCTGCTATGGGCGT
CTGCGTGCCGACCTCGAGCGCCGTGGCACGCCGATTGGCGCTAACGACATGCTGATCGCCGCCCATGCGCTCGCAATCGG
CGCGACCCTCGTTACCGACAACATCCGCGAATTCGAGCGGGTCGATGGCTTGCAACTGGTGAACTGGCTCCGAACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8322.49 Da        Isoelectric Point: 5.0336

>AT141851 WP_054764717.1 NZ_CP045456:c991741-991514 [Brevundimonas sp. Bb-A]
MRTTLAIDDDVLNAARALAAHQDRTVGEVMSELARQALQKRESTVRFRNGVPLLPDRPGPMVTLEDVNALRDELP

Download         Length: 228 bp

>AT141851 NZ_CP060122:2460055-2460288 [Sphingobium yanoikuyae]
ATGAACCTCGAGCGTCACGTCAAACTGTTCAAGAACGGCCGCAGCCAGGCGGTCCGCATTCCCCGTGAGTTCGAGCTTCC
GGGCGAGGACGCCATTATCCGCAAGGAAGGCTCGCGCCTGATCATCGAACCCGCCCGGCCGCGCTCCCTGCTTGCCGTTC
TCAAGACATGGGAACCGCTCGATGAAGAGATCGGCCCGATCGAGGACCTGCCAGCAGAACCGGTCGACATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0DC47

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0DI52

References