Detailed information of TA system TA141850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 945358..945982
• Replicon: chromosome
• Accession: NZ_CP045456
• Organism: Brevundimonas sp. Bb-A

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: BSP_RS04660
• Protein ID: WP_152949457.1
• Coordinates: 945358..945681 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BSP_RS04665
• Protein ID: WP_152949458.1
• Coordinates: 945674..945982 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSP_RS04640	941255..943012	-	1758	WP_152949455.1	hypothetical protein	-
BSP_RS04650	943457..943918	-	462	WP_054766821.1	TIGR02300 family protein	-
BSP_RS04655	944043..945353	+	1311	WP_152949456.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
BSP_RS04660	945358..945681	+	324	WP_152949457.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSP_RS04665	945674..945982	+	309	WP_152949458.1	putative addiction module antidote protein	Antitoxin
BSP_RS04670	945982..946626	+	645	WP_152949459.1	(d)CMP kinase	-
BSP_RS04675	946784..948487	+	1704	WP_152949460.1	30S ribosomal protein S1	-
BSP_RS04680	948804..949094	+	291	WP_152949461.1	integration host factor subunit beta	-
BSP_RS04685	949120..949536	+	417	WP_152949462.1	large-conductance mechanosensitive channel protein MscL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (15-104)

Antitoxin

• Uncharacterized protein HI1420 (5-94)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12279.98 Da
• Isoelectric Point: 10.1283

>T141850 WP_152949457.1 NZ_CP045456:945358-945681 [Brevundimonas sp. Bb-A]
MSPIDDNVATRLTFTPVFDRWLLRLRDQRAVARITTRLQRLSRGQWGDVKPVGEGVSELRIAYGPGYRLYAMKKNEAWVI
LLAGGDKSSQDRDIAEAKRLAEEYRND

Nucleotide

• Length: 324 bp

>T141850 NZ_CP060122:1896361-1896792 [Sphingobium yanoikuyae]
ATGAGCTTCCTGCTCGACACCAACATCATCTCGGAAGGCGCACGGCCGCGTCCCGATCCCGGCGTGATGGAATGGCTGGC
ATCGATGGATGAGGAAGAGTTGTTCCTGAGCGTCGTATCGGTGGCCGAACTGCGCCATGGGATCGAGCGCATGGACAAGG
GCGCGCGACAGGCGGGCCTCGACATCTGGCTGACCGAGCAACTGGCCCCGCGATTTGAAGACAGACTGCTCTCCATCGAC
AGCGTAACGGCGGACCTGTGGGGCCGGATCGTCGCCCGCGCGCAAGGCGCGGGCCGACCCATCGGCGCGATGGACGCTTT
CATTGCTGCCCATGCCCAGCAGCATCAACTGACACTCGTGACGCGCAATATCTCCGACTTCGAGGCGACCGGCATCCGCC
TCTTCAACCCTTGGACCGAAGGGAAAGCCTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11197.81 Da
• Isoelectric Point: 4.4128

>AT141850 WP_152949458.1 NZ_CP045456:945674-945982 [Brevundimonas sp. Bb-A]
MTEPLIEFDPARYLNTPEAVEEYLVSSFEEAAELGDPRIITNALGVVARAKGMTQMARDAELSRTALYRALSEEGRPELS
TIFKVMQALGLRLAPVRVDSAA

Nucleotide

• Length: 309 bp

>AT141850 NZ_CP060122:1896095-1896364 [Sphingobium yanoikuyae]
ATGGCGGTTGAAACGCATCCGGATAGCTGGACTGTTGCGCAGGCCAAGGCACGGCTGAGCGAGGTCATCGAAAAGGCGCG
GCGCGAACCCCAGGCGATTACCCGCCACGGCAAGAGCGCCGTCGTCGTGGTGGATGCCGGACTATGGGAACGGGTCCAGC
GCCGCCAGCATCGCGGTAGCTTCGCCGACTTCCTGCTGACCTCGCCGCTGCGCGGATCAGGGCTTGAGGTGGAGCGTCTC
AAGGACGGCGTGCGCGAGATCGATCTATGA