Detailed information of TA system TA141849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 17209..17796
• Replicon: plasmid pSDIE1
• Accession: NZ_CP045454
• Organism: Sulfurospirillum sp. ACSTCE

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FA592_RS14030
• Protein ID: WP_167751060.1
• Coordinates: 17563..17796 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FA592_RS14025
• Protein ID: WP_167751059.1
• Coordinates: 17209..17550 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FA592_RS13980	12620..12895	-	276	WP_167751050.1	hypothetical protein	-
FA592_RS13985	12937..13086	-	150	WP_167751051.1	HTH domain-containing protein	-
FA592_RS13990	13819..13980	-	162	WP_167751052.1	hypothetical protein	-
FA592_RS13995	13977..14561	-	585	WP_167751053.1	replication initiation protein	-
FA592_RS14000	14733..14984	-	252	WP_167751054.1	hypothetical protein	-
FA592_RS14005	15307..15516	-	210	WP_167751055.1	ParB N-terminal domain-containing protein	-
FA592_RS14010	15489..15668	-	180	WP_167751056.1	hypothetical protein	-
FA592_RS14015	15708..16322	-	615	WP_167751057.1	ParA family protein	-
FA592_RS14020	16351..16548	-	198	WP_167751058.1	ParA family protein	-
FA592_RS14025	17209..17550	-	342	WP_167751059.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FA592_RS14030	17563..17796	-	234	WP_167751060.1	type II toxin-antitoxin system HicA family toxin	Toxin
FA592_RS14035	18085..18393	-	309	WP_167751061.1	hypothetical protein	-
FA592_RS14040	18571..18999	+	429	WP_167751062.1	hypothetical protein	-
FA592_RS14045	20558..20857	-	300	WP_167751063.1	hypothetical protein	-
FA592_RS14050	20883..21038	-	156	WP_167751064.1	hypothetical protein	-
FA592_RS14055	21176..21415	-	240	WP_167751065.1	hypothetical protein	-
FA592_RS14060	21402..21755	-	354	WP_167751066.1	metallophosphoesterase	-
FA592_RS14065	21760..22065	-	306	WP_167751067.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..38046	38046

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (22-74)

Antitoxin

• Uncharacterised protein family HicB (55-103)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 9072.65 Da
• Isoelectric Point: 9.9313

>T141849 WP_167751060.1 NZ_CP045454:c17796-17563 [Sulfurospirillum sp. ACSTCE]
MSKRDKLWIKFMEVPPKKNLTWSDLLALMSALDFVQLEGDGSRVKFYHHAKDIVLNLHKPHPDNLLKTYLVKQIQEN

Nucleotide

• Length: 234 bp

>T141849 NZ_CP060122:1896095-1896364 [Sphingobium yanoikuyae]
ATGGCGGTTGAAACGCATCCGGATAGCTGGACTGTTGCGCAGGCCAAGGCACGGCTGAGCGAGGTCATCGAAAAGGCGCG
GCGCGAACCCCAGGCGATTACCCGCCACGGCAAGAGCGCCGTCGTCGTGGTGGATGCCGGACTATGGGAACGGGTCCAGC
GCCGCCAGCATCGCGGTAGCTTCGCCGACTTCCTGCTGACCTCGCCGCTGCGCGGATCAGGGCTTGAGGTGGAGCGTCTC
AAGGACGGCGTGCGCGAGATCGATCTATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12756.50 Da
• Isoelectric Point: 5.5805

>AT141849 WP_167751059.1 NZ_CP045454:c17550-17209 [Sulfurospirillum sp. ACSTCE]
MANVLTYENYTGSVEYSHEDRCFFGKIEFINDLITFEATTVDELEANFKEAVESYILTCKALNKPQKQFNGVFNVRPGVE
LHMAAARKAMEIGVSLNAYIKSLIAKDTHFSAH

Nucleotide

• Length: 342 bp

>AT141849 NZ_CP060122:1896361-1896792 [Sphingobium yanoikuyae]
ATGAGCTTCCTGCTCGACACCAACATCATCTCGGAAGGCGCACGGCCGCGTCCCGATCCCGGCGTGATGGAATGGCTGGC
ATCGATGGATGAGGAAGAGTTGTTCCTGAGCGTCGTATCGGTGGCCGAACTGCGCCATGGGATCGAGCGCATGGACAAGG
GCGCGCGACAGGCGGGCCTCGACATCTGGCTGACCGAGCAACTGGCCCCGCGATTTGAAGACAGACTGCTCTCCATCGAC
AGCGTAACGGCGGACCTGTGGGGCCGGATCGTCGCCCGCGCGCAAGGCGCGGGCCGACCCATCGGCGCGATGGACGCTTT
CATTGCTGCCCATGCCCAGCAGCATCAACTGACACTCGTGACGCGCAATATCTCCGACTTCGAGGCGACCGGCATCCGCC
TCTTCAACCCTTGGACCGAAGGGAAAGCCTGA