Detailed information of TA system TA141848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4500783..4501399
• Replicon: chromosome
• Accession: NZ_CP045451
• Organism: Enterobacter hormaechei strain 14320055602

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GEA57_RS21185
• Protein ID: WP_077266491.1
• Coordinates: 4500783..4501154 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6G4MTK3
• Locus tag: GEA57_RS21190
• Protein ID: WP_015569912.1
• Coordinates: 4501157..4501399 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEA57_RS21170	4498283..4499185	+	903	WP_014072386.1	formate dehydrogenase subunit beta	-
GEA57_RS21175	4499182..4499817	+	636	WP_003861958.1	formate dehydrogenase cytochrome b556 subunit	-
GEA57_RS21180	4499814..4500743	+	930	WP_003861956.1	formate dehydrogenase accessory protein FdhE	-
GEA57_RS21185	4500783..4501154	-	372	WP_077266491.1	type II toxin-antitoxin system VapC family toxin	Toxin
GEA57_RS21190	4501157..4501399	-	243	WP_015569912.1	ribbon-helix-helix domain-containing protein	Antitoxin
GEA57_RS21195	4501599..4502519	+	921	WP_017382675.1	alpha/beta hydrolase	-
GEA57_RS21200	4502528..4503469	-	942	WP_015569910.1	fatty acid biosynthesis protein FabY	-
GEA57_RS21205	4503514..4503951	-	438	WP_015569909.1	D-tyrosyl-tRNA(Tyr) deacylase	-
GEA57_RS21210	4503948..4504829	-	882	WP_003861949.1	virulence factor BrkB family protein	-
GEA57_RS21215	4504823..4505422	-	600	WP_203436019.1	glucose-1-phosphatase	-
GEA57_RS21220	4505541..4506341	-	801	WP_017382673.1	DeoR/GlpR family DNA-binding transcription regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13723.85 Da
• Isoelectric Point: 6.4882

>T141848 WP_077266491.1 NZ_CP045451:c4501154-4500783 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Nucleotide

• Length: 372 bp

>T141848 NZ_CP060122:c792686-792378 [Sphingobium yanoikuyae]
ATGGCGCGCTATCGTCTGACCCGCGCGGCGTCGGACGATATCGCAGCGATCTTCATCGACGGGATCGAACGGTTTGGGCT
GGTGCAGGCCGATCTCTATCATGCCGGGTTGGCGGCGGCTTTCGACCTGATTGCCGAATATCCTTTTGCAGTGCGACTGC
GGGAGGAGATCGTGCCGCCGGTACGGGTGCGCCACTATCGGGCGCATCTGATTCTTTATGATCTGGTCGAGGATAGCCGG
CCCCTCATCCTGCGGGTCCGCCATGGTCGGGAAGACTGGCAGGCGCGGGAGGAAGGGCCGGATCGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9440.72 Da
• Isoelectric Point: 4.4076

>AT141848 WP_015569912.1 NZ_CP045451:c4501399-4501157 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT141848 NZ_CP060122:c792933-792688 [Sphingobium yanoikuyae]
ATGGCGACAATGAATATTTCTCTGCCCGATCCGATGAAGAACTGGGTCGAGGCACAGACGGCAACCGGCCGTTACAGCAA
TGCGAGCGATTATGTGCGTGACCTGATCCGGCGCGATCAGGAGCGGCTGGCGAAGGTCGCCCATATGCAGATGCTGGTCG
ATGAAGCGCGGCAGGGCGGGATCAGCGACGAGACGATGGAGGATATCCGCGTGCGGGCGCTGCATCAGGCCGGGTTGAAG
CGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A6G4MTK3