Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3711239..3711896 Replicon chromosome
Accession NZ_CP045451
Organism Enterobacter hormaechei strain 14320055602

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag GEA57_RS17430 Protein ID WP_017382887.1
Coordinates 3711239..3711649 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GEA57_RS17435 Protein ID WP_003863437.1
Coordinates 3711630..3711896 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA57_RS17410 3707237..3708970 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
GEA57_RS17415 3708976..3709689 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GEA57_RS17420 3709718..3710614 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
GEA57_RS17425 3710716..3711237 + 522 WP_015571793.1 flavodoxin FldB -
GEA57_RS17430 3711239..3711649 - 411 WP_017382887.1 protein YgfX Toxin
GEA57_RS17435 3711630..3711896 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GEA57_RS17440 3712191..3713171 + 981 WP_017692714.1 tRNA-modifying protein YgfZ -
GEA57_RS17445 3713283..3713942 - 660 WP_003863433.1 hemolysin III family protein -
GEA57_RS17450 3714209..3714940 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
GEA57_RS17455 3715057..3716490 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T141847 WP_017382887.1 NZ_CP045451:c3711649-3711239 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T141847 NZ_CP060121:c4411721-4411464 [Escherichia coli BL21]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT141847 WP_003863437.1 NZ_CP045451:c3711896-3711630 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT141847 NZ_CP060121:c4411452-4410907 [Escherichia coli BL21]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References