Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1085408..1086028 Replicon chromosome
Accession NZ_CP045451
Organism Enterobacter hormaechei strain 14320055602

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag GEA57_RS05135 Protein ID WP_015571250.1
Coordinates 1085408..1085626 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GEA57_RS05140 Protein ID WP_006809850.1
Coordinates 1085654..1086028 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA57_RS05105 1081420..1081680 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
GEA57_RS05110 1081683..1081823 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GEA57_RS05115 1081820..1082530 - 711 WP_032670463.1 GNAT family N-acetyltransferase -
GEA57_RS05120 1082632..1084092 + 1461 WP_045334455.1 PLP-dependent aminotransferase family protein -
GEA57_RS05125 1084064..1084531 - 468 WP_203436142.1 hypothetical protein -
GEA57_RS05130 1084648..1085199 - 552 WP_015571251.1 maltose O-acetyltransferase -
GEA57_RS05135 1085408..1085626 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
GEA57_RS05140 1085654..1086028 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GEA57_RS05145 1086539..1089685 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
GEA57_RS05150 1089708..1090901 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T141836 WP_015571250.1 NZ_CP045451:c1085626-1085408 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T141836 NZ_CP060121:1432514-1432690 [Escherichia coli BL21]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT141836 WP_006809850.1 NZ_CP045451:c1086028-1085654 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT141836 NZ_CP060121:1432736-1433152 [Escherichia coli BL21]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References