Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4574597..4575213 Replicon chromosome
Accession NZ_CP045450
Organism Enterobacter hormaechei strain 14280161202

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GEA58_RS21725 Protein ID WP_077266491.1
Coordinates 4574597..4574968 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag GEA58_RS21730 Protein ID WP_015569912.1
Coordinates 4574971..4575213 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA58_RS21710 4572097..4572999 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
GEA58_RS21715 4572996..4573631 + 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
GEA58_RS21720 4573628..4574557 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
GEA58_RS21725 4574597..4574968 - 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
GEA58_RS21730 4574971..4575213 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
GEA58_RS21735 4575412..4576332 + 921 WP_062938426.1 alpha/beta hydrolase -
GEA58_RS21740 4576341..4577282 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
GEA58_RS21745 4577327..4577764 - 438 WP_063135442.1 D-tyrosyl-tRNA(Tyr) deacylase -
GEA58_RS21750 4577761..4578642 - 882 WP_003861949.1 virulence factor BrkB family protein -
GEA58_RS21755 4578636..4579235 - 600 WP_047055778.1 glucose-1-phosphatase -
GEA58_RS21760 4579354..4580154 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T141833 WP_077266491.1 NZ_CP045450:c4574968-4574597 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

>T141833 NZ_CP060121:c1227121-1227014 [Escherichia coli BL21]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT141833 WP_015569912.1 NZ_CP045450:c4575213-4574971 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT141833 NZ_CP060121:1227168-1227234 [Escherichia coli BL21]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References