Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4450859..4451466 Replicon chromosome
Accession NZ_CP045450
Organism Enterobacter hormaechei strain 14280161202

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag GEA58_RS21175 Protein ID WP_071788668.1
Coordinates 4451281..4451466 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8H9RQ79
Locus tag GEA58_RS21170 Protein ID WP_032651934.1
Coordinates 4450859..4451266 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA58_RS21140 4446700..4447353 + 654 WP_032672255.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
GEA58_RS21145 4447356..4448216 + 861 WP_032672254.1 L-ribulose-5-phosphate 3-epimerase -
GEA58_RS21150 4448210..4448905 + 696 WP_015572759.1 L-ribulose-5-phosphate 4-epimerase -
GEA58_RS21155 4448906..4449193 - 288 Protein_4127 helix-turn-helix domain-containing protein -
GEA58_RS21160 4449188..4449577 + 390 Protein_4128 glycoside hydrolase family 127 protein -
GEA58_RS21165 4449779..4450855 + 1077 WP_032668994.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
GEA58_RS21170 4450859..4451266 - 408 WP_032651934.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GEA58_RS21175 4451281..4451466 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
GEA58_RS21180 4451716..4453254 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
GEA58_RS21185 4453421..4454305 + 885 WP_015572761.1 ROK family protein -
GEA58_RS21190 4454309..4456147 - 1839 WP_126291938.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T141832 WP_071788668.1 NZ_CP045450:c4451466-4451281 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T141832 NZ_CP060121:c1226586-1226479 [Escherichia coli BL21]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15110.90 Da        Isoelectric Point: 4.3197

>AT141832 WP_032651934.1 NZ_CP045450:c4451266-4450859 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR

Download         Length: 408 bp

>AT141832 NZ_CP060121:1226636-1226699 [Escherichia coli BL21]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGATTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure

References