Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3785438..3786095 Replicon chromosome
Accession NZ_CP045450
Organism Enterobacter hormaechei strain 14280161202

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag GEA58_RS17940 Protein ID WP_017382887.1
Coordinates 3785438..3785848 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GEA58_RS17945 Protein ID WP_003863437.1
Coordinates 3785829..3786095 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA58_RS17920 3781436..3783169 - 1734 WP_059294895.1 single-stranded-DNA-specific exonuclease RecJ -
GEA58_RS17925 3783175..3783888 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GEA58_RS17930 3783917..3784813 - 897 WP_203453065.1 site-specific tyrosine recombinase XerD -
GEA58_RS17935 3784915..3785436 + 522 WP_015571793.1 flavodoxin FldB -
GEA58_RS17940 3785438..3785848 - 411 WP_017382887.1 protein YgfX Toxin
GEA58_RS17945 3785829..3786095 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GEA58_RS17950 3786390..3787370 + 981 WP_047062486.1 tRNA-modifying protein YgfZ -
GEA58_RS17955 3787482..3788141 - 660 WP_203453066.1 hemolysin III family protein -
GEA58_RS17960 3788408..3789139 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
GEA58_RS17965 3789256..3790689 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T141831 WP_017382887.1 NZ_CP045450:c3785848-3785438 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T141831 NZ_CP060121:c449354-449136 [Escherichia coli BL21]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT141831 WP_003863437.1 NZ_CP045450:c3786095-3785829 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT141831 NZ_CP060121:c449754-449380 [Escherichia coli BL21]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References