Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3077827..3079610 Replicon chromosome
Accession NZ_CP045450
Organism Enterobacter hormaechei strain 14280161202

Toxin (Protein)


Gene name hipA Uniprot ID A0A2G5A822
Locus tag GEA58_RS14665 Protein ID WP_045333653.1
Coordinates 3077827..3079176 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2G5A843
Locus tag GEA58_RS14670 Protein ID WP_045333654.1
Coordinates 3079173..3079610 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA58_RS14640 3073650..3074585 - 936 WP_015572323.1 tRNA dihydrouridine(16) synthase DusC -
GEA58_RS14645 3074754..3075149 + 396 WP_032671768.1 CidA/LrgA family protein -
GEA58_RS14650 3075146..3075841 + 696 WP_015572322.1 CidB/LrgB family autolysis modulator -
GEA58_RS14655 3075970..3076854 + 885 WP_032671769.1 cytidine deaminase -
GEA58_RS14660 3076982..3077692 + 711 WP_017383381.1 outer membrane permeability protein SanA -
GEA58_RS14665 3077827..3079176 + 1350 WP_045333653.1 HipA domain-containing protein Toxin
GEA58_RS14670 3079173..3079610 + 438 WP_045333654.1 helix-turn-helix domain-containing protein Antitoxin
GEA58_RS14675 3079649..3080659 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
GEA58_RS14680 3080675..3082195 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
GEA58_RS14685 3082275..3083273 - 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
GEA58_RS14690 3083569..3084591 - 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51197.84 Da        Isoelectric Point: 4.6562

>T141829 WP_045333653.1 NZ_CP045450:3077827-3079176 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRTLINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPTT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

>T141829 NZ_CP060121:256867-257265 [Escherichia coli BL21]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16171.61 Da        Isoelectric Point: 10.5154

>AT141829 WP_045333654.1 NZ_CP045450:3079173-3079610 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT141829 NZ_CP060121:256571-256864 [Escherichia coli BL21]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G5A822

Antitoxin

Source ID Structure
AlphaFold DB A0A2G5A843

References