Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1093804..1094424 Replicon chromosome
Accession NZ_CP045450
Organism Enterobacter hormaechei strain 14280161202

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag GEA58_RS05155 Protein ID WP_015571250.1
Coordinates 1093804..1094022 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GEA58_RS05160 Protein ID WP_006809850.1
Coordinates 1094050..1094424 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA58_RS05125 1089816..1090076 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
GEA58_RS05130 1090079..1090219 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GEA58_RS05135 1090216..1090926 - 711 WP_033486653.1 GNAT family N-acetyltransferase -
GEA58_RS05140 1091028..1092488 + 1461 WP_063134751.1 PLP-dependent aminotransferase family protein -
GEA58_RS05145 1092460..1092927 - 468 WP_023296041.1 hypothetical protein -
GEA58_RS05150 1093044..1093595 - 552 WP_015571251.1 maltose O-acetyltransferase -
GEA58_RS05155 1093804..1094022 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
GEA58_RS05160 1094050..1094424 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GEA58_RS05165 1094935..1098081 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
GEA58_RS05170 1098104..1099297 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T141816 WP_015571250.1 NZ_CP045450:c1094022-1093804 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T141816 NZ_CP060117:3126061-3126168 [Shigella sonnei]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT141816 WP_006809850.1 NZ_CP045450:c1094424-1094050 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT141816 NZ_CP060117:c3126016-3125950 [Shigella sonnei]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References