Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 584289..584954 Replicon chromosome
Accession NZ_CP045450
Organism Enterobacter hormaechei strain 14280161202

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag GEA58_RS02790 Protein ID WP_203453156.1
Coordinates 584649..584954 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GEA58_RS02785 Protein ID WP_203453155.1
Coordinates 584289..584612 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA58_RS02755 579301..580086 + 786 WP_203453149.1 hypothetical protein -
GEA58_RS02760 580303..580521 - 219 WP_203453150.1 helix-turn-helix domain-containing protein -
GEA58_RS02765 580616..581263 - 648 WP_203453151.1 inovirus Gp2 family protein -
GEA58_RS02770 581807..582763 + 957 WP_203453152.1 hypothetical protein -
GEA58_RS02775 582913..583734 + 822 WP_203453153.1 DUF945 domain-containing protein -
GEA58_RS02780 583806..584276 + 471 WP_203453154.1 DNA repair protein RadC -
GEA58_RS02785 584289..584612 + 324 WP_203453155.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GEA58_RS02790 584649..584954 + 306 WP_203453156.1 TA system toxin CbtA family protein Toxin
GEA58_RS02795 585090..585299 + 210 Protein_536 restriction endonuclease -
GEA58_RS02800 585480..586349 - 870 WP_047062282.1 HNH endonuclease -
GEA58_RS02805 586651..587118 + 468 WP_203453157.1 SymE family type I addiction module toxin -
GEA58_RS02810 587177..587548 - 372 WP_047062283.1 hypothetical protein -
GEA58_RS02815 588123..589127 - 1005 WP_126291410.1 tryptophan--tRNA ligase -
GEA58_RS02820 589327..589752 + 426 WP_058685932.1 FosA/FosA2 family fosfomycin resistance glutathione transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 570599..589127 18528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-100)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11532.10 Da        Isoelectric Point: 5.9595

>T141815 WP_203453156.1 NZ_CP045450:584649-584954 [Enterobacter hormaechei]
MHISSVPATVPVSSRLSPVRVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRYEQ
TSFLTATDILKARRATRLINT

Download         Length: 306 bp

>T141815 NZ_CP060117:c2706988-2706698 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11969.81 Da        Isoelectric Point: 7.7096

>AT141815 WP_203453155.1 NZ_CP045450:584289-584612 [Enterobacter hormaechei]
MSITPPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTGVFTPKQLQKLDQFFPLFISQLEAMLCSGKLNPQQQQQGT
IQLMGLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT141815 NZ_CP060117:c2707182-2706988 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References