Detailed information of TA system TA141814

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 305983..306579
• Replicon: chromosome
• Accession: NZ_CP045450
• Organism: Enterobacter hormaechei strain 14280161202

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: GEA58_RS01445
• Protein ID: WP_023295756.1
• Coordinates: 306277..306579 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: A0A927HL08
• Locus tag: GEA58_RS01440
• Protein ID: WP_023295755.1
• Coordinates: 305983..306270 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEA58_RS01435	304355..305986	+	1632	WP_003860350.1	Na/Pi cotransporter family protein	-
GEA58_RS01440	305983..306270	-	288	WP_023295755.1	putative addiction module antidote protein	Antitoxin
GEA58_RS01445	306277..306579	-	303	WP_023295756.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GEA58_RS01450	306777..307649	+	873	WP_003860347.1	23S rRNA pseudouridine(2604) synthase RluF	-
GEA58_RS01455	307650..307922	-	273	WP_017382612.1	DUF3811 domain-containing protein	-
GEA58_RS01460	307973..308917	-	945	WP_023295757.1	ketopantoate/pantoate/pantothenate transporter PanS	-
GEA58_RS01465	309011..310360	-	1350	WP_006810501.1	lysine-sensitive aspartokinase 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-93)

Antitoxin

• Uncharacterized protein HI1420 (3-90)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11441.24 Da
• Isoelectric Point: 10.1042

>T141814 WP_023295756.1 NZ_CP045450:c306579-306277 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Nucleotide

• Length: 303 bp

>T141814 NZ_CP060117:2377187-2377290 [Shigella sonnei]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10101.59 Da
• Isoelectric Point: 5.7807

>AT141814 WP_023295755.1 NZ_CP045450:c306270-305983 [Enterobacter hormaechei]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Nucleotide

• Length: 288 bp

>AT141814 NZ_CP060117:c2377291-2377057 [Shigella sonnei]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGGTCATCAGCTTAAATGATAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT