Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 86959..88582 Replicon plasmid p280_9355
Accession NZ_CP045446
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain 9355

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag GEO45_RS23050 Protein ID WP_000088046.1
Coordinates 87257..88582 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag GEO45_RS23045 Protein ID WP_024136327.1
Coordinates 86959..87252 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEO45_RS23015 82831..84072 + 1242 WP_001053338.1 VWA domain-containing protein -
GEO45_RS23020 84635..84916 - 282 WP_000077926.1 hypothetical protein -
GEO45_RS23025 84966..85157 - 192 WP_000398480.1 hypothetical protein -
GEO45_RS23030 85249..85590 - 342 WP_001151575.1 hypothetical protein -
GEO45_RS23035 85963..86355 + 393 WP_000341066.1 hypothetical protein -
GEO45_RS23045 86959..87252 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
GEO45_RS23050 87257..88582 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
GEO45_RS23055 88643..88849 + 207 WP_000134171.1 hypothetical protein -
GEO45_RS23060 88951..89241 + 291 WP_000985910.1 hypothetical protein -
GEO45_RS23070 89283..90119 - 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
GEO45_RS23075 90119..90922 - 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
GEO45_RS23085 92223..92837 - 615 WP_000904906.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / aac(3)-IVa / aph(4)-Ia / tet(A) / sul1 / blaCTX-M-2 / qacE / ant(3'')-Ia / dfrA1 / tet(B) - 1..276821 276821


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T141812 WP_000088046.1 NZ_CP045446:87257-88582 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T141812 NZ_CP060117:c1411377-1410835 [Shigella sonnei]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT141812 WP_024136327.1 NZ_CP045446:86959-87252 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT141812 NZ_CP060117:c1411672-1411361 [Shigella sonnei]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References