Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2252421..2252935 Replicon chromosome
Accession NZ_CP045435
Organism Staphylococcus aureus strain 08-028

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag SA08028_RS11425 Protein ID WP_000581793.1
Coordinates 2252421..2252630 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag SA08028_RS11430 Protein ID WP_000138932.1
Coordinates 2252642..2252935 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA08028_RS11405 2247930..2249288 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SA08028_RS11410 2249303..2250373 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
SA08028_RS11415 2250691..2251893 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SA08028_RS11420 2252156..2252293 - 138 WP_000828354.1 hypothetical protein -
SA08028_RS11425 2252421..2252630 - 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
SA08028_RS11430 2252642..2252935 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
SA08028_RS11435 2253101..2254585 + 1485 WP_000571549.1 cardiolipin synthase -
SA08028_RS11440 2254613..2255260 + 648 WP_001187628.1 HD domain-containing protein -
SA08028_RS11445 2255874..2256746 - 873 WP_000725802.1 membrane protein insertase YidC -
SA08028_RS11450 2256832..2257473 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T141805 WP_000581793.1 NZ_CP045435:c2252630-2252421 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T141805 NZ_CP060111:4656672-4656890 [Klebsiella michiganensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCAGCGGCCGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT141805 WP_000138932.1 NZ_CP045435:c2252935-2252642 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT141805 NZ_CP060111:4656271-4656645 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGACCCGACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGATGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCTGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References