Detailed information of TA system TA141799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2032870..2033646
• Replicon: chromosome
• Accession: NZ_CP045435
• Organism: Staphylococcus aureus strain 08-028

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: SA08028_RS10075
• Protein ID: WP_000031108.1
• Coordinates: 2032870..2033022 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: SA08028_RS10080
• Protein ID: WP_001251224.1
• Coordinates: 2033047..2033646 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA08028_RS10060	2029006..2029827	+	822	WP_179976071.1	RluA family pseudouridine synthase	-
SA08028_RS10065	2030288..2031673	-	1386	WP_000116229.1	class II fumarate hydratase	-
SA08028_RS10070	2031869..2032264	-	396	WP_000901023.1	hypothetical protein	-
SA08028_RS10075	2032870..2033022	-	153	WP_000031108.1	hypothetical protein	Toxin
SA08028_RS10080	2033047..2033646	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
SA08028_RS10085	2033805..2034275	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
SA08028_RS10090	2034280..2035407	-	1128	WP_000379987.1	tRNA epoxyqueuosine(34) reductase QueG	-
SA08028_RS10095	2035558..2036280	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
SA08028_RS10100	2036273..2037730	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T141799 WP_000031108.1 NZ_CP045435:c2033022-2032870 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T141799 NZ_CP060111:695277-695651 [Klebsiella michiganensis]
ATGAAATGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGCATTTTACAACATCTCCCCGGCGTTAAAGGTATGTC
CGATCCTGGTCGGGCGGAAGCCATAATTTATCGTGTACAGAACCGCTTTCACTATGAAGGGGTGAACGACATTTTTGAAC
TGGCTGCAACCTATTGGGTCGCTATCGCGCGTGGGCACATTTTTAATGATGGTAATAAGAGGACTGCTTTTTTTATCACC
ATGACGTTCCTGGCCCGCAATGGGTATCTTATCGCTGATGAAGATACCCGGTTGGAAGAACTCACTGTGCTGGCTGCGAC
AGGCGAAGCTACGGTAGTGGTTCTTGCTGATGCGTTACGGCAATTGGCGCTCTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT141799 WP_001251224.1 NZ_CP045435:c2033646-2033047 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT141799 NZ_CP060111:695059-695280 [Klebsiella michiganensis]
ATGCGCTCATACAGTACATCTGAAGCCAGACAGAATATTGCGGCCGTCATGGACGCCGCTGCCAGCGGAGAACCGATTGA
AATTACACGGCGTGATGGAACGTCTAATGTTTTGATCAGTAAGGCGGAATATGAAACGTTTATGAATGCCAAACTTGATG
CGGAGTTTGATTTTATTATGCAGCGACACGGCCGCACAGTTAAGGCGTTGACCGATCGATGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4