Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1652732..1653520 Replicon chromosome
Accession NZ_CP045435
Organism Staphylococcus aureus strain 08-028

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag SA08028_RS08180 Protein ID WP_000525004.1
Coordinates 1653059..1653520 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SA08028_RS08175 Protein ID WP_000333630.1
Coordinates 1652732..1653046 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA08028_RS08115 1647875..1649041 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
SA08028_RS08120 1649038..1649400 - 363 WP_000985984.1 hypothetical protein -
SA08028_RS08125 1649415..1649738 - 324 WP_000175001.1 hypothetical protein -
SA08028_RS08130 1649817..1649978 - 162 WP_001285954.1 DUF1270 domain-containing protein -
SA08028_RS08135 1649991..1650253 - 263 Protein_1602 helix-turn-helix domain-containing protein -
SA08028_RS08140 1650278..1650493 - 216 WP_001097552.1 hypothetical protein -
SA08028_RS08145 1650548..1650913 + 366 WP_001128433.1 hypothetical protein -
SA08028_RS08150 1650882..1651127 - 246 WP_001025401.1 DUF2829 domain-containing protein -
SA08028_RS08155 1651183..1651392 + 210 WP_000642492.1 hypothetical protein -
SA08028_RS08160 1651382..1651525 - 144 WP_000939498.1 hypothetical protein -
SA08028_RS08165 1651554..1652330 - 777 WP_001148544.1 Rha family transcriptional regulator -
SA08028_RS08170 1652344..1652580 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
SA08028_RS08175 1652732..1653046 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
SA08028_RS08180 1653059..1653520 + 462 WP_000525004.1 hypothetical protein Toxin
SA08028_RS08185 1653538..1654122 + 585 WP_000825948.1 hypothetical protein -
SA08028_RS08190 1654352..1654498 + 147 WP_001013104.1 hypothetical protein -
SA08028_RS08195 1654495..1655109 - 615 Protein_1614 ATPase -
SA08028_RS08200 1655235..1656440 + 1206 WP_020444721.1 site-specific integrase -
SA08028_RS08205 1656483..1658509 - 2027 Protein_1616 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gnd 1610933..1679022 68089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T141796 WP_000525004.1 NZ_CP045435:1653059-1653520 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T141796 NZ_CP060096:388511-388861 [Aceticella autotrophica]
ATGGTTATAAAAAGAGGAGATATTTTATATGCTGATTTAAGCCCTGTAATTGGCTCTGAACAGGGGGGGGTAAGACCTGT
ACTTGTGATACAAAATGATATTGGCAATAAATACAGTCCAACAGTTATAGTTTCGGCTATTACTTCACAGATAAACAAGG
CAAAGCTTCCTACACATGTGGAGATAAACGGGACTGAATTTGGACTAAATAAAGATTCTGTTATTCTTCTTGAACAGATA
AGAACAATTGATAAAAAAAGATTGAGGGAAAAGATAGGGCATTTCGATCAGGAAATGATGGATAAGGTAAATGAAGCACT
GCAAATAAGCCTCGGACTCATTGATTTTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT141796 WP_000333630.1 NZ_CP045435:1652732-1653046 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT141796 NZ_CP060096:388234-388509 [Aceticella autotrophica]
GTGGGCGAGACAAAAAGAATACTCGTCAGTTTGCCGGAGAGTTTGCTTGAAGAAGTTGATATTCTTGCAGCGATGGAAAA
TAGAAACCGCAGTGAATTCATAAGAGAAGCTATGAGGTTGTACATCAGGGAAAGAAAAAAGATGAAGATACGTGAAAGCA
TGAAAAAAGGCTACCTTGAGATGGGTACGATCAATGCTGAACTTGCGGAAATGAGCCTAACCGCCGAAAATGAATGTTTT
TTAAGATATGAAAGGAAATTAAAAAAGTGTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References