Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 889298..889775 Replicon chromosome
Accession NZ_CP045435
Organism Staphylococcus aureus strain 08-028

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SA08028_RS04335 Protein ID WP_000052076.1
Coordinates 889298..889486 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SA08028_RS04340 Protein ID WP_001059690.1
Coordinates 889515..889775 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA08028_RS04305 885392..885913 + 522 WP_000824464.1 hypothetical protein -
SA08028_RS04310 886150..886836 + 687 WP_001793574.1 thermonuclease family protein -
SA08028_RS04315 887193..887393 + 201 WP_001059082.1 cold-shock protein -
SA08028_RS04320 887889..888107 - 219 WP_000005886.1 hypothetical protein -
SA08028_RS04325 888169..888453 - 285 WP_001004401.1 hypothetical protein -
SA08028_RS04330 888541..889110 - 570 WP_001106654.1 hypothetical protein -
SA08028_RS04335 889298..889486 - 189 WP_000052076.1 hypothetical protein Toxin
SA08028_RS04340 889515..889775 - 261 WP_001059690.1 hypothetical protein Antitoxin
SA08028_RS04345 890115..890318 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SA08028_RS04350 890315..890551 - 237 WP_000368687.1 hypothetical protein -
SA08028_RS04355 890775..891356 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SA08028_RS04360 891405..892022 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
SA08028_RS04365 892177..892671 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SA08028_RS04370 893069..893491 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
SA08028_RS04375 893639..894355 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)

Antitoxin

Toxin YoeB

(10-89)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T141792 WP_000052076.1 NZ_CP045435:c889486-889298 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T141792 NZ_CP060089:c50778-50524 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTTAAAGCTGTTTTAGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAAGATGCCGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACAGTTCACT
TACTACGCTCTCCTCAAAACGCTGAACATCTAAATCGCTCGATTGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATCGATGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT141792 WP_001059690.1 NZ_CP045435:c889775-889515 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT141792 NZ_CP060089:c50531-50262 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAACGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAACAAACTCATCAATGATATTAAGCGTTCCTCATTTGAGGGCATCGGTAAACCAGAGCCATTAA
AAGAGAACTTATCTGGCTTTTGGTCTCGCCGTATTGATGACACTAATAGGCTTGTTTACGCAGTCGATGACCAAGCTATA
ACGATAATTTCGTGTCGTTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References