Detailed information of TA system TA141785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1787601..1789237
• Replicon: chromosome
• Accession: NZ_CP045428
• Organism: Acinetobacter baumannii strain AbCAN2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: F9K57_RS08580
• Protein ID: WP_159142048.1
• Coordinates: 1787906..1789237 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: F9K57_RS08575
• Protein ID: WP_001101310.1
• Coordinates: 1787601..1787909 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9K57_RS08550	1783366..1784250	+	885	WP_159142046.1	prolyl oligopeptidase family serine peptidase	-
F9K57_RS08555	1784303..1784830	-	528	WP_001016251.1	hypothetical protein	-
F9K57_RS08560	1785002..1785544	+	543	WP_001002974.1	RNA 2'-phosphotransferase	-
F9K57_RS08565	1785569..1786156	-	588	WP_159142047.1	hypothetical protein	-
F9K57_RS08570	1786330..1786878	-	549	WP_171519566.1	TetR family transcriptional regulator	-
F9K57_RS08575	1787601..1787909	-	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
F9K57_RS08580	1787906..1789237	-	1332	WP_159142048.1	HipA domain-containing protein	Toxin
F9K57_RS08585	1789533..1789988	+	456	WP_159142049.1	HD domain-containing protein	-
F9K57_RS08590	1790009..1790653	-	645	WP_159142050.1	hypothetical protein	-
F9K57_RS08595	1790665..1791636	-	972	WP_159142051.1	5'/3'-nucleotidase SurE	-
F9K57_RS08600	1791763..1792926	-	1164	WP_159142052.1	hypothetical protein	-
F9K57_RS08605	1792919..1794157	-	1239	WP_159142560.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51201.26 Da
• Isoelectric Point: 4.9059

>T141785 WP_159142048.1 NZ_CP045428:c1789237-1787906 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIENLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T141785 NZ_CP060086:c5441957-5441547 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACCATCAAAAACCGTCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGTCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT141785 WP_001101310.1 NZ_CP045428:c1787909-1787601 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT141785 NZ_CP060086:c5442199-5441957 [Pseudomonas aeruginosa]
ATGAGGTGTGTCGTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCT
TCCTGATGACGTTAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGTGAGTCTTGGGATA
GCTGGTTCGATGGCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTC
TGA