Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 735661..737270 Replicon chromosome
Accession NZ_CP045427
Organism Shewanella sp. YLB-09

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FS418_RS03170 Protein ID WP_142874865.1
Coordinates 735942..737270 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FS418_RS03165 Protein ID WP_142874866.1
Coordinates 735661..735942 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS418_RS03145 730913..732610 - 1698 WP_142874867.1 MtrB/PioB family outer membrane beta-barrel protein -
FS418_RS03150 732620..733480 - 861 WP_142873541.1 DmsE family decaheme c-type cytochrome -
FS418_RS03155 733972..734610 - 639 WP_142874875.1 multidrug MFS transporter -
FS418_RS03160 734775..735470 + 696 WP_142874874.1 amino acid adenylation -
FS418_RS03165 735661..735942 + 282 WP_142874866.1 helix-turn-helix domain-containing protein Antitoxin
FS418_RS03170 735942..737270 + 1329 WP_142874865.1 type II toxin-antitoxin system HipA family toxin Toxin
FS418_RS03175 737577..738149 - 573 WP_142874864.1 hypothetical protein -
FS418_RS03180 738599..739150 - 552 WP_142874863.1 hypothetical protein -
FS418_RS03185 739163..739831 - 669 WP_185965875.1 nucleotidyltransferase domain-containing protein -
FS418_RS03190 739914..740531 - 618 WP_142874861.1 tyrosine-type recombinase/integrase -
FS418_RS03195 740543..740731 - 189 WP_142874860.1 hypothetical protein -
FS418_RS03200 740786..742153 - 1368 WP_185965874.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49676.02 Da        Isoelectric Point: 6.5059

>T141781 WP_142874865.1 NZ_CP045427:735942-737270 [Shewanella sp. YLB-09]
MAILDVYMNGYFIGEFTKSTTGSHLFKYEQQWLDISGSRPISLSMPLRKHEYKGDEVYNFFDNLLPDNTDVRNRIVARHN
AQSTQAFDLLYKVGQDSVGALQLVPHDQNAFDVKKIESKPLSDKELEKVLKGYQSDIPLGMLADEDDFRISIAGAQEKTA
LLNLDGQWHLPIKATPTTHIIKLPIGEIQSHSHTIDMSDSVENEYLCMMIVREFGLDVPQCSIIQVGDIKALTVERFDRK
LSTDGKWIMRLPQEDFCQTLNIPPAKKYESHGGPGIEQIMPYLLGSKNAERDRYNFMKSQVLFWLLAATDGHAKNFSLFI
EAGGGYRLTPFYDILSISPAIGGKGLNIRNAKLAMGLKATKGKEYRIAQIFPRHFIQTAKAIGYDTDAMAYIMSELADVV
DSVVTKVKSQLPIDFPVHIRDSILDGLEARANRLVNLAPVNM

Download         Length: 1329 bp

>T141781 NZ_CP060086:1965881-1966468 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTTGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGAATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10577.97 Da        Isoelectric Point: 5.8701

>AT141781 WP_142874866.1 NZ_CP045427:735661-735942 [Shewanella sp. YLB-09]
MKVTNSKQLSAYLKDARLNMKLSQSKVGNKVGIRQDTVSSFEQNPDSTKLETLFKILSALNLELDVKVRNPELGGEIHDD
KAITSDQEWKEEW

Download         Length: 282 bp

>AT141781 NZ_CP060086:1966535-1967389 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATTATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References