Detailed information of TA system TA141773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 3656800..3657326
• Replicon: chromosome
• Accession: NZ_CP045422
• Organism: Devosia sp. S02

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: GDR53_RS17770
• Protein ID: WP_210321449.1
• Coordinates: 3656800..3657045 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: GDR53_RS17775
• Protein ID: WP_193335753.1
• Coordinates: 3657042..3657326 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GDR53_RS17755	3652408..3653787	+	1380	WP_193335749.1	trigger factor	-
GDR53_RS17760	3653882..3655354	+	1473	WP_193335750.1	NAD(P)H-hydrate epimerase	-
GDR53_RS17765	3655365..3656621	-	1257	WP_193335751.1	cytochrome P450	-
GDR53_RS17770	3656800..3657045	+	246	WP_210321449.1	BrnT family toxin	Toxin
GDR53_RS17775	3657042..3657326	+	285	WP_193335753.1	BrnA antitoxin family protein	Antitoxin
GDR53_RS17780	3657349..3657579	+	231	WP_193335754.1	hypothetical protein	-
GDR53_RS17785	3657896..3658525	+	630	WP_193335755.1	ATP-dependent Clp protease proteolytic subunit	-
GDR53_RS17790	3658698..3659975	+	1278	WP_193335756.1	ATP-dependent Clp protease ATP-binding subunit ClpX	-
GDR53_RS17795	3660097..3660504	+	408	WP_193335757.1	DUF1801 domain-containing protein	-
GDR53_RS17800	3660508..3661590	-	1083	WP_193335758.1	citrate synthase/methylcitrate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-77)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (20-91)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9008.34 Da
• Isoelectric Point: 5.5740

>T141773 WP_210321449.1 NZ_CP045422:3656800-3657045 [Devosia sp. S02]
IEIIWDEPKRRANLAKHGLDFADLDEDFFNDAVVVTAHSGRRMAIGWFEGVGIVVIHVVYGLEAISVISMRRASAAERSV
L

Nucleotide

• Length: 246 bp

>T141773 NZ_CP060084:3681298-3681597 [Teredinibacter haidensis]
ATGAGCTATAGCCTCGAATTTAAAAAGAGTGCTTTAAAAGAATGGATAAAGCTCGCCCCATCAATACGACAAGTATTTAA
AAAGAAACTAACCGAACGACTTGAAAACCCTCATGTGCTTTCCGCTGCTGTTAGCGGCGGGAATAACTTATACAAAATTA
AATTACGCCAACTTGGCTACCGCTTAGTATATTCAGTTTCCGATACAACAATTACAGTGACCGTTCTTGCTGCAGGAAAA
AGAAACCGTAACGAAGTCTATGATTTGGCGCTTTCTCGTGATGACCCCGACAAGCTATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10589.97 Da
• Isoelectric Point: 8.5771

>AT141773 WP_193335753.1 NZ_CP045422:3657042-3657326 [Devosia sp. S02]
MSSDFKPGQGYTREDWDAVDSPELTAEELATARPFAAVFPELAENIRRSRGRPKIEAPKQQISLRLDSEVIEKFKATGKG
WQSRINDVLKATKL

Nucleotide

• Length: 285 bp

>AT141773 NZ_CP060084:3681060-3681308 [Teredinibacter haidensis]
ATGCCAAATCAAATACTTACCGAAATGGCTGCAAGCATTTCTGAGCTAAAAGCCAACCCCATGAAGGTTGTTGCTAGCGG
TGAAGGTATGCCAATAGCCGTGCTAAACAGGAACGAACCAGCCTTTTATTGCATCCCAGCTAAAGCCTACGAGGCTATGA
TGGACCTCATAGAAGATAAAGACCTTCTAGAGGTAGCCAGAAGCCGCATGGATGAAGAAAGCGTAAAGGTGAAACTGGAT
GAGCTATAG