Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 67125..68038 Replicon plasmid pTHAF12_a
Accession NZ_CP045400
Organism Halomonas sp. THAF12

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FIU88_RS18160 Protein ID WP_152480357.1
Coordinates 67125..67589 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FIU88_RS18165 Protein ID WP_152480358.1
Coordinates 67586..68038 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU88_RS18110 62149..62331 + 183 WP_152480347.1 hypothetical protein -
FIU88_RS18115 62318..62689 + 372 WP_152480348.1 hypothetical protein -
FIU88_RS18120 62811..63005 + 195 WP_152480349.1 hypothetical protein -
FIU88_RS18125 63037..63750 + 714 WP_152480350.1 DUF2786 domain-containing protein -
FIU88_RS18130 63773..64090 + 318 WP_152480351.1 hypothetical protein -
FIU88_RS18135 64101..64640 + 540 WP_152480352.1 hypothetical protein -
FIU88_RS18140 64647..64946 + 300 WP_152480353.1 hypothetical protein -
FIU88_RS18145 64975..66252 - 1278 WP_152480354.1 Y-family DNA polymerase -
FIU88_RS18150 66252..66722 - 471 WP_152480355.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
FIU88_RS18155 66850..67062 + 213 WP_152480356.1 hypothetical protein -
FIU88_RS18160 67125..67589 - 465 WP_152480357.1 RES family NAD+ phosphorylase Toxin
FIU88_RS18165 67586..68038 - 453 WP_152480358.1 DUF2384 domain-containing protein Antitoxin
FIU88_RS18170 68348..68596 - 249 WP_152480359.1 helix-turn-helix domain-containing protein -
FIU88_RS18175 68684..68965 - 282 WP_152480360.1 hypothetical protein -
FIU88_RS18180 69207..69434 + 228 WP_152480361.1 hypothetical protein -
FIU88_RS18185 69476..69712 + 237 WP_152480362.1 hypothetical protein -
FIU88_RS18190 69766..71409 + 1644 WP_152480363.1 phosphoadenosine phosphosulfate reductase family protein -
FIU88_RS18195 71537..72031 - 495 WP_152480364.1 hypothetical protein -
FIU88_RS18200 72238..72813 - 576 WP_152480365.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..169237 169237


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(7-145)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(96-147)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17241.66 Da        Isoelectric Point: 4.4444

>T141766 WP_152480357.1 NZ_CP045400:c67589-67125 [Halomonas sp. THAF12]
MTSVRGYRLVKRKWLKTAFDGEGARLYGGRWNSKGKACVYLASTESLAMLEVMVHLEDNQLLKEYALLEVTFPEELLMQL
PEDVLPADWRAEPAPPSTAEIGDDWLEGQSSLALALPSVVAPRERNYLVNPDHPDFQALVDGAEEVVFAPDKRL

Download         Length: 465 bp

>T141766 NZ_CP060083:3848827-3849045 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16763.43 Da        Isoelectric Point: 10.1136

>AT141766 WP_152480358.1 NZ_CP045400:c68038-67586 [Halomonas sp. THAF12]
MEAAIKEYRPKLKRRKDDFWKALGLPPRGAKLHEALSEGVSYKVYIKLTEASGLESKELARYVVIPPATLKRRADTGYFK
PAEGDRLYRFAEVYKSAVDLFEGDKAKAREWLLSPVRGLGGRRPVEMVATTAGAEAVLDLIGRLEHGVFA

Download         Length: 453 bp

>AT141766 NZ_CP060083:3848427-3848801 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References