Detailed information of TA system TA141764

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1919762..1921330
• Replicon: chromosome
• Accession: NZ_CP045399
• Organism: Halomonas sp. THAF12

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FIU88_RS08920
• Protein ID: WP_152478965.1
• Coordinates: 1920026..1921330 (+)
• Length: 435 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FIU88_RS08915
• Protein ID: WP_016854935.1
• Coordinates: 1919762..1920022 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU88_RS08895	1915213..1916541	+	1329	WP_152478961.1	MATE family efflux transporter	-
FIU88_RS08900	1916682..1918334	+	1653	WP_152478962.1	nitrite/sulfite reductase	-
FIU88_RS08905	1918327..1918845	+	519	WP_152478963.1	DUF934 domain-containing protein	-
FIU88_RS08910	1919014..1919604	-	591	WP_152478964.1	DNA endonuclease SmrA	-
FIU88_RS08915	1919762..1920022	+	261	WP_016854935.1	helix-turn-helix domain-containing protein	Antitoxin
FIU88_RS08920	1920026..1921330	+	1305	WP_152478965.1	type II toxin-antitoxin system HipA family toxin	Toxin
FIU88_RS08925	1921411..1921839	+	429	WP_152478966.1	gamma-glutamylcyclotransferase	-
FIU88_RS08930	1921963..1922430	+	468	WP_016854938.1	MgtC/SapB family protein	-
FIU88_RS08935	1922529..1922870	+	342	WP_152478967.1	arsenate reductase (glutaredoxin)	-
FIU88_RS08940	1922902..1923519	+	618	WP_152478968.1	NAD(P)H:quinone oxidoreductase	-
FIU88_RS08945	1923516..1923911	+	396	WP_152478969.1	DUF2069 domain-containing protein	-
FIU88_RS08950	1924132..1924773	+	642	WP_152478970.1	pyridoxamine 5'-phosphate oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-64)

Sequences

Toxin

Protein

• Length: 435 a.a.
• Molecular weight: 48036.75 Da
• Isoelectric Point: 6.2471

>T141764 WP_152478965.1 NZ_CP045399:1920026-1921330 [Halomonas sp. THAF12]
MANLTVAMNGIEIGTLSLARSGAMAFQYRREWVDRPGARAVSLSLPLSTAAYRGERVYNFFDNLLPDSEAIRARMQARFR
VPTRHPFDLLASIGRDCVGAIQLTPEDAPCGDVHGVGAEPLDDRAIEALLSGYQDAPLGMAEGQDFRISLAGAQEKTALL
WHQGRWQRPTGSTPTSHIFKLPIGFLEHSNIDLRQSNANEWLCLRLLEAFGLPAAQTELARFGDQEVLVVERFDRRWSRD
GSWLMRLPQEDFCQALGIAPALKYESDGGPGIAQGMRLLRGSQQAGVDRERFFKAQILFWLLAAIDGHAKNFSLFLEPGS
AYRMTPMYDVISAYPLMHQGSMAAERAKMAMALKGKNRHYRWSRMAPRHFIATAEQVEYSPERVTALMEEIAGSAGRIVG
DLDADLPGDFPAATSDPILEGVLQQASRLADFLA

Nucleotide

• Length: 1305 bp

>T141764 NZ_CP060083:c2765508-2765332 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGTGTCACCCTAGCGATGAGATTAAAGAACCATTGCGTAAAGCAATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9757.89 Da
• Isoelectric Point: 6.0746

>AT141764 WP_016854935.1 NZ_CP045399:1919762-1920022 [Halomonas sp. THAF12]
MKITSPEMLAHSLKNARTRRQLTQQATAEQIGIKQSTVSGFEHHPERSRLETLFKLLSALELELHVTERDSTDASASPEA
GWDQEW

Nucleotide

• Length: 261 bp

>AT141764 NZ_CP060083:c2765286-2764870 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA