Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1839718..1841372 Replicon chromosome
Accession NZ_CP045399
Organism Halomonas sp. THAF12

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FIU88_RS08560 Protein ID WP_152478913.1
Coordinates 1840026..1841372 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FIU88_RS08555 Protein ID WP_016854861.1
Coordinates 1839718..1840029 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU88_RS08540 1834962..1835171 - 210 WP_152478910.1 hypothetical protein -
FIU88_RS08545 1835321..1836571 + 1251 WP_152478911.1 HlyD family efflux transporter periplasmic adaptor subunit -
FIU88_RS08550 1836568..1839708 + 3141 WP_152478912.1 efflux RND transporter permease subunit -
FIU88_RS08555 1839718..1840029 - 312 WP_016854861.1 helix-turn-helix domain-containing protein Antitoxin
FIU88_RS08560 1840026..1841372 - 1347 WP_152478913.1 type II toxin-antitoxin system HipA family toxin Toxin
FIU88_RS08565 1841517..1842182 + 666 WP_152478914.1 SDR family oxidoreductase -
FIU88_RS08570 1842176..1843033 + 858 WP_152478915.1 3'(2'),5'-bisphosphate nucleotidase CysQ -
FIU88_RS08575 1843191..1843496 + 306 WP_152478916.1 hypothetical protein -
FIU88_RS08580 1843961..1845550 + 1590 WP_152478917.1 peptide chain release factor 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-389)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50683.22 Da        Isoelectric Point: 5.7668

>T141763 WP_152478913.1 NZ_CP045399:c1841372-1840026 [Halomonas sp. THAF12]
MQLTIQIHHQARWQDAALLEIPAPERGTRGPARMGYFQDYALAWMFHDDEHACSLTLPVELMMTHRGDRWFGFLEDIMPA
GASRRYWIDHLGLQDLDAGQQDSELLRLGTIAPVGNLRIREALPERPPGDALASLRFPLEDVLERHTDFLEYAQQMGAAS
GGATGAGGEAPKLLIRRTPERQVWIDTWQDDTTTPDAHYLVKFPRGSRSDDDCDILRAEYHYYRELHALGVDTVPLEGLE
LHEGTRYPSLWLPRFDVEWRQGQLHRHGLESVYALLGAAPGTHLRHPAVIRRLVALLKGQHRVREGNEPFDTAAFVVDWV
TRDLLNLAFGNSDNHGRNAALLKRPEGIWHAPVYDFAPMKADPEGVTRTTQWGPEFERGGDVDWPAVAEHLADLVEPERL
MGELRALGERLTGLRDRLANRGVPSRILDMPAVGLNHLDDRLTRWGLT

Download         Length: 1347 bp

>T141763 NZ_CP060083:2677629-2678951 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11528.30 Da        Isoelectric Point: 8.7469

>AT141763 WP_016854861.1 NZ_CP045399:c1840029-1839718 [Halomonas sp. THAF12]
MKPQARSPEARQAALLEQLRLLMRGETTEGRVLRTLRREVLGLTQTAYAELVGVSRRTLSDIERDAGNASMASLDRVFRP
LGLRVGLMPRQPELLAELLDDES

Download         Length: 312 bp

>AT141763 NZ_CP060083:2677363-2677629 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References