Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 19001..19590 Replicon plasmid pTHAF33_b
Accession NZ_CP045386
Organism Ruegeria sp. THAF33

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FIU92_RS20905 Protein ID WP_152460666.1
Coordinates 19001..19294 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FIU92_RS20910 Protein ID WP_152460667.1
Coordinates 19300..19590 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU92_RS20880 14571..14873 - 303 WP_152460662.1 SH3 domain-containing protein -
FIU92_RS20885 14976..15368 - 393 WP_152460663.1 GFA family protein -
FIU92_RS20890 15620..15871 + 252 WP_152460843.1 WGR domain-containing protein -
FIU92_RS20895 16397..16801 + 405 WP_152460664.1 DUF3768 domain-containing protein -
FIU92_RS20900 17020..18885 + 1866 WP_152460665.1 ParB/RepB/Spo0J family partition protein -
FIU92_RS20905 19001..19294 + 294 WP_152460666.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIU92_RS20910 19300..19590 + 291 WP_152460667.1 putative addiction module antidote protein Antitoxin
FIU92_RS20915 19613..20155 + 543 WP_152460668.1 hypothetical protein -
FIU92_RS20920 20840..21040 + 201 WP_152460669.1 hypothetical protein -
FIU92_RS20925 21513..21932 + 420 WP_152460670.1 hypothetical protein -
FIU92_RS20930 21929..23758 + 1830 WP_152460671.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..214580 214580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(4-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10805.61 Da        Isoelectric Point: 10.2926

>T141760 WP_152460666.1 NZ_CP045386:19001-19294 [Ruegeria sp. THAF33]
MIEIRKTNLFDKWLTGLKDQRARARILVRITRLSLGNPGDVKPVGEGVSELRISEGKGYRVYYVSRGDVLIILLCGGDKS
SQQADIKTAKAMAKELE

Download         Length: 294 bp

>T141760 NZ_CP060083:2240051-2240154 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10054.39 Da        Isoelectric Point: 4.7361

>AT141760 WP_152460667.1 NZ_CP045386:19300-19590 [Ruegeria sp. THAF33]
MGVKTTKFEAADYLDSPEAIQAYLEAAFETSDTALIASALGDVAKAKGMSSVADKSGLSRESLYRALSENGNPEFGTVLK
VLSAVGVTLTPKMHVN

Download         Length: 291 bp

>AT141760 NZ_CP060083:c2240192-2239921 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References